MilliporeSigma

HLA-DRA

major histocompatibility complex, class II, DR alpha

Synonyms:
HLA-DRA1, MLRW
Species:
UniProtKB ID:
Gene ID:
  • Human(3122) Summary: HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. [provided by RefSeq, Jul 2008]

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Antibodies

Product Number
Description
Species Reactivity
Application
Monoclonal Anti-HLA-DR antibody produced in mouse, clone L243, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
dog, human, nonhuman primates
Application
FUNC
flow cytometry

immunocytochemistry

immunohistochemistry

immunoprecipitation (IP)

western blot
Anti-HLA-DRA antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-HLA-DRA antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-HLA-DRA antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Anti-HLA-DRA antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot

Proteins

Product Number
Description
Species
PrEST Antigen HLA-DRA, Prestige Antigens Powered by Atlas Antibodies, buffered aqueous solution,
Species
human
PrEST Antigen HLA-DRA, Prestige Antigens Powered by Atlas Antibodies, buffered aqueous solution,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human HLA-DRA (1),
Species
human
MISSION® esiRNA, targeting human HLA-DRA (2),
Species
human