MilliporeSigma

HTR1A

5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled

Synonyms:
5-HT-1A, 5-HT1A, 5HT1a, ADRB2RL1, ADRBRL1, G-21, PFMCD
Species:
UniProtKB ID:
Gene ID:
  • Human(3350) Summary: This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic fevers. [provided by RefSeq, Jun 2012]
  • Mouse(15550) 5-hydroxytryptamine (serotonin) receptor 1A
  • Rat(24473) 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
  • chicken(431581) 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
  • naked mole-rat(101718872) 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
  • dog(487230) 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
  • domestic guinea pig(100301563) 5-hydroxytryptamine (serotonin) receptor 1A
  • cow(407137) 5-hydroxytryptamine (serotonin) receptor 1A
  • Horse(100009683) 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
  • domestic cat(101101542) 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
  • Domestic Rabbit(100008780) 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
  • sheep(101105852) 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled

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Small Molecule - Agonist

Product Number
Description
Species
Buspirone hydrochloride, ,
Species
human
(R)-(+)-8-Hydroxy-DPAT hydrobromide, ≥98% (HPLC), solid,
Species
human
Buspirone hydrochloride, United States Pharmacopeia (USP) Reference Standard,
Species
human
Buspirone hydrochloride, European Pharmacopoeia (EP) Reference Standard,
Species
human
Buspirone for system suitability, European Pharmacopoeia (EP) Reference Standard,
Species
human

Small Molecule - Allosteric Modulator

Product Number
Description
Species
DCEBIO, ≥98% (HPLC), solid,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
1-(3-Methoxyphenyl)piperazine, 95%,
Species
rat
1-(3-Chlorophenyl)piperazine hydrochloride, 99%,
Species
rat
GR 103691, ≥98% (HPLC), solid,
Species
rat
WAY-100635 maleate salt, powder,
Species
human
1-(4-Methoxyphenyl)piperazine, 97%,
Species
mouse, rat

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-5-HT-1A antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot
Anti-HTR1A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-Serotonin Antibody, clone YC5/45, culture supernatant, clone YC5/45, Chemicon®,
Species Reactivity
human, lizard, mouse, pig, rabbit, rat
Application
immunohistochemistry
Anti-5HT1A antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-Htr1a antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot

Small Molecule - Blocker

Product Number
Description
Species
Trazodone hydrochloride, ≥99% (HPLC), powder,
Species
human
(S)-(−)-Propranolol hydrochloride, ≥98% (TLC), powder,
Species
human
Trimipramine maleate salt, ≥98% (TLC), powder,
Species
human
Zimelidine dihydrochloride, solid,
Species
human

Small Molecule - Inhibitor

Product Number
Description
Species
Vilazodone hydrochloride, ≥98% (HPLC),
Species
human
Vilazodone hydrochloride solution, 1 mg/mL (Methanol:DMSO (90:10) (v/v)), certified reference material, ampule of 1 mL, Cerilliant®,
Species
human
1,2,3,4-Tetrahydroisoquinoline, 95%,
Species
rat, human
Trazodone hydrochloride, ≥99% (HPLC), powder,
Species
human
S-(+)-Fluoxetine hydrochloride, ≥98% (HPLC), solid,
Species
human

Small Molecule - Ligand

Product Number
Description
Species
Nω-Methyl-5-hydroxy­trypt­amine oxalate salt, ≥90% (HPLC),
Species
human

Small Molecule - Metabolite

Product Number
Description
Species
5-Hydroxyindole-3-acetic acid, ≥98% (HPLC), crystalline,
Species
human

Small Molecule - Mixed Agonist/Antagonist

Product Number
Description
Species
BP897, >98% (HPLC), solid,
Species
human, rat
Mifepristone, ≥98%,
Species
human, mouse, rat
Haloperidol, powder,
Species
human, rat
Clozapine, ,
Species
human, rat

Small Molecule - Precursor

Product Number
Description
Species
5-Hydroxy-L-tryptophan, powder,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human HTR1A,
Species
human