MilliporeSigma

HTR3A

5-hydroxytryptamine (serotonin) receptor 3A, ionotropic

Synonyms:
5-HT-3, 5-HT3A, 5-HT3R, 5HT3R, HTR3
Species:
UniProtKB ID:
Gene ID:
  • Human(3359) Summary: The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
  • Mouse(15561) 5-hydroxytryptamine (serotonin) receptor 3A
  • Rat(79246) 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
  • Domestic Rabbit(100009570) 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
  • chicken(428247) 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
  • domestic guinea pig(100135547) 5-hydroxytryptamine (serotonin) receptor 3A
  • Horse(100009690) 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
  • naked mole-rat(101714088) 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
  • sheep(101110536) 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
  • dog(489399) 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
  • cow(617674) 5-hydroxytryptamine (serotonin) receptor 3A
  • domestic cat(101098004) 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic

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Small Molecule - Agonist

Product Number
Description
Species
Metoclopramide hydrochloride, British Pharmacopoeia (BP) Reference Standard,
Species
human
Metoclopramide, VETRANAL®, analytical standard,
Species
human
Metoclopramide, European Pharmacopoeia (EP) Reference Standard,
Species
human
SR 57227A, solid,
Species
human
Metoclopramide hydrochloride, solid,
Species
human

Small Molecule - Allosteric Modulator

Product Number
Description
Species
DCEBIO, ≥98% (HPLC), solid,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
Ondansetron hydrochloride dihydrate, British Pharmacopoeia (BP) Reference Standard,
Species
human
Ondansetron hydrochloride, United States Pharmacopeia (USP) Reference Standard,
Species
human
1-(4-Chlorophenyl)piperazine, ≥98.0% (GC),
Species
rat
Ondansetron Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human
Ondansetron for TLC system suitability, European Pharmacopoeia (EP) Reference Standard,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-HTR3A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunohistochemistry
Anti-Serotonin receptor 3A/HTR3A, from rabbit, purified by affinity chromatography,
Species Reactivity
human
Application
immunohistochemistry
western blot

Small Molecule - Blocker

Product Number
Description
Species
Trimipramine maleate salt, ≥98% (TLC), powder,
Species
human
Zimelidine dihydrochloride, solid,
Species
human

Small Molecule - Inhibitor

Product Number
Description
Species
S-(+)-Fluoxetine hydrochloride, ≥98% (HPLC), solid,
Species
human
R-(−)-Fluoxetine hydrochloride, >98% (HPLC), solid,
Species
human
Sertraline hydrochloride, ≥98% (HPLC),
Species
human
Fluvoxamine maleate, solid,
Species
human
Fluoxetine hydrochloride, solid,
Species
human

Small Molecule - Ligand

Product Number
Description
Species
Nω-Methyl-5-hydroxy­trypt­amine oxalate salt, ≥90% (HPLC),
Species
human

Small Molecule - Metabolite

Product Number
Description
Species
5-Hydroxyindole-3-acetic acid, ≥98% (HPLC), crystalline,
Species
human

Small Molecule - Precursor

Product Number
Description
Species
5-Hydroxy-L-tryptophan, powder,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Htr3a,
Species
mouse
MISSION® esiRNA, targeting human HTR3A,
Species
human