MilliporeSigma

HTT

huntingtin

Synonyms:
HD, IT15
Species:
UniProtKB ID:
Gene ID:
  • Human(3064) Summary: Huntingtin is a disease gene linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. A fairly broad range in the number of trinucleotide repeats has been identified in normal controls, and repeat numbers in excess of 40 have been described as pathological. The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widely expressed. The genetic defect leading to Huntington's disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein. One candidate is the huntingtin-associated protein-1, highly expressed in brain, which has increased affinity for huntingtin protein with expanded polyglutamine repeats. This gene contains an upstream open reading frame in the 5' UTR that inhibits expression of the huntingtin gene product through translational repression. [provided by RefSeq, Jul 2008]
  • Mouse(15194) huntingtin
  • Rat(29424) huntingtin
  • chicken(422878) huntingtin
  • Zebrafish(30214) huntingtin
  • fruit fly(43392) huntingtin
  • dog(479074) huntingtin
  • cow(615059) huntingtin
  • domestic cat(101086476) huntingtin
  • naked mole-rat(101697599) huntingtin
  • domestic guinea pig(100713322) huntingtin

Custom & Knockdown Gene Products

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-HTT Mouse mAb (3F1), liquid, clone 3F1, Calbiochem®,
Species Reactivity
human
Application
Anti-Huntingtin Protein Antibody, clone 1M11, ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human, mouse, rat
Application
flow cytometry
immunocytochemistry

immunohistochemistry

western blot
Anti-polyQ Disease Proteins Antibody, clone 3B5H10, clone 3B5H10, from mouse,
Species Reactivity
human
Application
electron microscopy
immunocytochemistry

immunohistochemistry

inhibition assay

western blot
Anti-Huntingtin antibody produced in rabbit, ,
Species Reactivity
human, mouse
Application
immunohistochemistry
western blot
Monoclonal Anti-HD antibody produced in mouse, clone 3F1, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunohistochemistry

western blot

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human HTT,
Species
human
MISSION® esiRNA, targeting mouse Htt,
Species
mouse