MilliporeSigma

ABAT

4-aminobutyrate aminotransferase

Synonyms:
GABA-AT, GABAT, NPD009
Species:
UniProtKB ID:
Gene ID:
  • Human(18) Summary: 4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(268860) 4-aminobutyrate aminotransferase
  • Rat(81632) 4-aminobutyrate aminotransferase
  • Horse(100051470) 4-aminobutyrate aminotransferase
  • cow(280969) 4-aminobutyrate aminotransferase
  • sheep(101105462) 4-aminobutyrate aminotransferase
  • Goat(100861058) 4-aminobutyrate aminotransferase
  • domestic guinea pig(100725419) 4-aminobutyrate aminotransferase
  • domestic cat(101089064) 4-aminobutyrate aminotransferase
  • naked mole-rat(101712584) 4-aminobutyrate aminotransferase
  • chicken(416642) 4-aminobutyrate aminotransferase
  • Zebrafish(378968) 4-aminobutyrate aminotransferase
  • dog(479856) 4-aminobutyrate aminotransferase

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-GABA transaminase (ABAT) Antibody, clone 10V1K9, Rabbit Monoclonal, ,
Species Reactivity
human, rat
Application
immunohistochemistry
western blot
Anti-ABAT antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, goat, guinea pig, human, mouse, rabbit, rat
Application
western blot
Anti-ABAT antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
Anti-ABAT antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
Vigabatrin, British Pharmacopoeia (BP) Reference Standard,
Species
human
Vigabatrin, European Pharmacopoeia (EP) Reference Standard,
Species
human
Vigabatrin solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Species
human
Vigabatrin, United States Pharmacopeia (USP) Reference Standard,
Species
human
(±)-Vigabatrin, ,
Species
human

Proteins

Product Number
Description
Species
PrEST Antigen ABAT, Prestige Antigens Powered by Atlas Antibodies, buffered aqueous solution,
Species
human
PrEST Antigen ABAT, Prestige Antigens Powered by Atlas Antibodies, buffered aqueous solution,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Abat,
Species
mouse
MISSION® esiRNA, targeting human ABAT,
Species
human
MISSION® esiRNA, targeting mouse Abat,
Species
mouse