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AGTR1

angiotensin II receptor, type 1

Synonyms:
AG2S, AGTR1A, AGTR1B, AT1, AT1AR, AT1B, AT1BR, AT1R, AT2R1, AT2R1A, AT2R1B, HAT1R
Species:
UniProtKB ID:
Gene ID:
  • Human(185) Summary: Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Jul 2012]
  • naked mole-rat(101714068) angiotensin II receptor, type 1
  • Domestic Rabbit(100009164) angiotensin II receptor, type 1
  • domestic guinea pig(100192325) angiotensin II receptor, type 1
  • sheep(443107) angiotensin II receptor, type 1
  • dog(403836) angiotensin II receptor, type 1
  • chicken(396065) angiotensin II receptor, type 1
  • cow(281607) angiotensin II receptor, type 1
  • domestic cat(101082936) angiotensin II receptor, type 1

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Small Molecule - Agonist

Product Number
Description
Species
ProteoMass Angiotensin II MALDI-MS Standard, vial of 10 nmol,
Species
human
[Val5]-Angiotensin II acetate salt hydrate, ≥95% (HPLC), powder,
Species
mouse, human, rat
[Asn1, Val5]-Angiotensin II, ≥97% (HPLC),
Species
mouse, human, rat

Small Molecule - Antagonist

Product Number
Description
Species
Losartan potassium, ,
Species
human
Eprosartan mesylate, ≥98% (HPLC),
Species
human
Valsartan, European Pharmacopoeia (EP) Reference Standard,
Species
human
Valsartan, United States Pharmacopeia (USP) Reference Standard,
Species
human
Valsartan for peak identification, European Pharmacopoeia (EP) Reference Standard,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-AGTR1/AT1 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse
Application
ELISA
western blot
Anti-AGTR1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, guinea pig, human, mouse, rabbit, rat, sheep
Application
western blot
Anti-AGTR1 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence

immunohistochemistry

western blot
Anti-AGTR1 Antibody, clone 1I12 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
bovine, canine, human, mouse, rat
Application
affinity binding assay
immunocytochemistry

western blot
Anti-AGTR1 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
Captopril, ≥98% (HPLC), powder,
Species
human, rat
2,2′:5′,2′′:5′′,2′′′-Quaterthiophene, 96%,
Species
human, rat, mouse

Proteins

Product Number
Description
Species
ChemiSCREEN Human Angiotensin II Receptor, Type I Membrane Preparation, Human AT1 GPCR membrane preparation for Radioligand binding Assays & GTPγS binding.,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human AGTR1,
Species
human