MilliporeSigma

ALOX5

arachidonate 5-lipoxygenase

Synonyms:
5-LO, 5-LOX, 5LPG, LOG5
Species:
UniProtKB ID:
Gene ID:
  • Human(240) Summary: This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
  • Mouse(11689) arachidonate 5-lipoxygenase
  • Rat(25290) arachidonate 5-lipoxygenase
  • sheep(101117390) arachidonate 5-lipoxygenase
  • naked mole-rat(101700210) arachidonate 5-lipoxygenase
  • Zebrafish(573013) arachidonate 5-lipoxygenase
  • Zebrafish(567204) arachidonate 5-lipoxygenase
  • chicken(423769) arachidonate 5-lipoxygenase
  • dog(477753) arachidonate 5-lipoxygenase
  • cow(404074) arachidonate 5-lipoxygenase
  • domestic cat(101097422) arachidonate 5-lipoxygenase
  • Horse(100062042) arachidonate 5-lipoxygenase
  • domestic guinea pig(100718093) arachidonate 5-lipoxygenase

Custom & Knockdown Gene Products

  • siRNA

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  • Custom Gene Products

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-Arachidonate 5 Lipoxygenase antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry

western blot
Anti-ALOX5 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human, mouse
Application
immunofluorescence
western blot
Anti-Phospho-ALOX5-S271 antibody produced in rabbit, ,
Species Reactivity
human
Application
western blot
Anti-ALOX5 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
Anti-ALOX5 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry

Small Molecule - Inhibitor

Product Number
Description
Species
1-Phenyl-3-pyrazolidinone, 97%,
Species
rat
Zileuton, ≥98% (HPLC),
Species
human
Zileuton, United States Pharmacopeia (USP) Reference Standard,
Species
human
Isoliquiritigenin, powder,
Species
rat
Caffeic acid, ≥98.0% (HPLC),
Species
human, rat

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human ALOX5,
Species
human
MISSION® esiRNA, targeting mouse Alox5,
Species
mouse