MilliporeSigma

CAMK2A

calcium/calmodulin-dependent protein kinase II alpha

Synonyms:
CAMKA
Species:
UniProtKB ID:
Gene ID:
  • Human(815) Summary: The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2008]
  • Mouse(12322) calcium/calmodulin-dependent protein kinase II alpha
  • Rat(25400) calcium/calmodulin-dependent protein kinase II alpha
  • Zebrafish(550436) calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha
  • Domestic Rabbit(100341507) calcium/calmodulin-dependent protein kinase II alpha
  • dog(612941) calcium/calmodulin-dependent protein kinase II alpha
  • domestic cat(101084342) calcium/calmodulin-dependent protein kinase II alpha
  • cow(530719) calcium/calmodulin-dependent protein kinase II alpha
  • naked mole-rat(101722229) calcium/calmodulin-dependent protein kinase II alpha
  • domestic guinea pig(100727059) calcium/calmodulin-dependent protein kinase II alpha
  • Horse(100071654) calcium/calmodulin-dependent protein kinase II alpha
  • chicken(374175) calcium/calmodulin-dependent protein kinase II alpha

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Small Molecule - Antagonist

Product Number
Description
Species
N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride, ,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-CAMK2A antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry

western blot
Anti-Phospho-Camk2a-T286 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-CaM Kinase II Antibody, from rabbit, purified by affinity chromatography,
Species Reactivity
bovine, chicken, guinea pig, hamster, human, mouse, rabbit, rat
Application
western blot
Anti-CAMK2A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
Anti-CAMK2A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry

Small Molecule - Inhibitor

Product Number
Description
Species
Adenine, BioReagent, suitable for plant cell culture, ≥99%,
Species
human, rat, mouse
Adenine, BioReagent, suitable for cell culture,
Species
human, rat, mouse
Adenine, ≥99%,
Species
human, rat, mouse

Proteins

Product Number
Description
Species
CAMK2α, active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human
Calmodulin-dependent Protein Kinase II fragment 290-309, ≥97% (HPLC),
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Camk2a,
Species
mouse
MISSION® esiRNA, targeting human CAMK2A,
Species
human

Small Molecule - Substrate

Product Number
Description
Species
Autocamtide 2-related inhibitory peptide, ≥97% (HPLC), lyophilized powder,
Species
mouse, rat, human