MilliporeSigma

CHRNA3

cholinergic receptor, nicotinic, alpha 3 (neuronal)

Synonyms:
LNCR2, NACHRA3, PAOD2
Species:
UniProtKB ID:
Gene ID:
  • Human(1136) Summary: This locus encodes a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. This locus encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues. The encoded protein is a ligand-gated ion channel that likely plays a role in neurotransmission. Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2009]
  • Mouse(110834) cholinergic receptor, nicotinic, alpha polypeptide 3
  • Rat(25101) cholinergic receptor, nicotinic, alpha 3 (neuronal)
  • domestic guinea pig(100730977) cholinergic receptor, nicotinic, alpha 3 (neuronal)
  • naked mole-rat(101701279) cholinergic receptor, nicotinic, alpha 3 (neuronal)
  • sheep(101123239) cholinergic receptor, nicotinic, alpha 3 (neuronal)
  • Domestic Rabbit(100342666) cholinergic receptor, nicotinic, alpha 3 (neuronal)
  • dog(482111) cholinergic receptor, nicotinic, alpha 3 (neuronal)
  • cow(282702) cholinergic receptor, nicotinic, alpha 3 (neuronal)
  • domestic cat(100037403) cholinergic receptor, nicotinic, alpha 3 (neuronal)
  • Zebrafish(568467) cholinergic receptor, nicotinic, alpha 3
  • chicken(386578) cholinergic receptor, nicotinic, alpha 3

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Small Molecule - Agonist

Product Number
Description
Species
(±)-Nicotine, ≥99% (TLC), liquid,
Species
human, rat
Carbamoylcholine chloride, ≥98% (titration), crystalline,
Species
human, mouse, rat
Tropisetron monohydrochloride, solid, ≥98% (HPLC),
Species
rat, human
(−)-Nicotine solution, 1.0 mg/mL, analytical standard, for drug analysis,
Species
human, mouse, rat
(−)-Nicotine, ≥99% (GC), liquid,
Species
human, mouse, rat

Small Molecule - Antagonist

Product Number
Description
Species
Cytisine, ≥99%, powder,
Species
rat
(±)-Nicotine, ≥99% (TLC), liquid,
Species
human, rat
Mecamylamine hydrochloride, ,
Species
human
Carbamoylcholine chloride, ≥98% (titration), crystalline,
Species
human, mouse, rat
Tropisetron monohydrochloride, solid, ≥98% (HPLC),
Species
rat, human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-CHRNA3 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
dog, human, rabbit
Application
western blot
Monoclonal Anti-Nicotinic Acetylcholine Receptor (α1, α3, α5 Subunits) antibody produced in rat, clone mAb 35, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
chicken, eel, human
Application
immunohistochemistry

Small Molecule - Blocker

Product Number
Description
Species
Hexamethonium chloride, solid (hygroscopic),
Species
human
Tetraethylammonium chloride, ≥98% (titration),
Species
human
Hexamethonium bromide, ,
Species
human
Kynurenic acid, ≥98%,
Species
rat, human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Chrna3,
Species
mouse
MISSION® esiRNA, targeting human CHRNA3,
Species
human