MilliporeSigma

CTLA4

cytotoxic T-lymphocyte-associated protein 4

Synonyms:
CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, IDDM12
Species:
UniProtKB ID:
Gene ID:
  • Human(1493) Summary: This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]
  • Mouse(12477) cytotoxic T-lymphocyte-associated protein 4
  • Rat(63835) cytotoxic T-lymphocyte-associated protein 4
  • domestic guinea pig(100725760) cytotoxic T-lymphocyte-associated protein 4
  • naked mole-rat(101722788) cytotoxic T-lymphocyte-associated protein 4
  • cow(281732) cytotoxic T-lymphocyte-associated protein 4
  • dog(403696) cytotoxic T-lymphocyte-associated protein 4
  • domestic cat(493743) cytotoxic T-lymphocyte-associated protein 4
  • chicken(424106) cytotoxic T-lymphocyte-associated protein 4
  • Domestic Rabbit(100009412) cytotoxic T-lymphocyte-associated protein 4

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

ELISA

Product Number
Description
Species
Human CXCL16 ELISA Kit, for serum, plasma, cell culture supernatant and urine,
Species
human
Mouse CTLA-4 ELISA Kit, for serum, plasma and cell culture supernatant,
Species
mouse

Antibodies

Product Number
Description
Species Reactivity
Application
Monoclonal Anti-CTLA4 antibody produced in mouse, clone 2F1, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence

western blot
ANTI-IDDM12(N-TERMINAL) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
Anti-CD152 (CTLA-4) Antibody (mouse), APC, clone UC10-4F10-11, clone UC10-4F10-11, 0.2 mg/mL, from hamster(Armenian),
Species Reactivity
mouse
Application
flow cytometry
Anti-CD152 (CTLA-4) (mouse), PE-Cy7, clone UC10-4F10-11 Antibody, clone UC10-4F10-11, from hamster(Armenian), PE-Cy7,
Species Reactivity
mouse
Application
flow cytometry
Anti-CD152 (CTLA-4) Antibody (mouse), APC, clone UC10-4F10-11, clone UC10-4F10-11, 0.2 mg/mL, from hamster(Armenian),
Species Reactivity
mouse
Application
flow cytometry

Proteins

Product Number
Description
Species
CD152 (human): FC (human) (non-lytic), recombinant, expressed in CHO cells, ≥98% (SDS-PAGE),
Species
human
CD152/Fc Chimera, Non-cytolytic from mouse, ≥98% (SDS-PAGE), recombinant, expressed in NS.1 cells, lyophilized,
Species
mouse
CD152/Fc Chimera, Cytolytic from mouse, recombinant, expressed in NS.1 cells, buffered aqueous solution,
Species
mouse

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human CTLA4,
Species
human