MilliporeSigma

CYP3A4

cytochrome P450, family 3, subfamily A, polypeptide 4

Synonyms:
CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1
Species:
UniProtKB ID:
Gene ID:
  • Human(1576) Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2011]
  • Horse(100294525) cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4
  • cow(507988) cytochrome P450, subfamily IIIA, polypeptide 4
  • dog(479740) cytochrome P450, family 3, subfamily A, polypeptide 4
  • chicken(416477) cytochrome P450, family 3, subfamily A, polypeptide 4

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Antibodies

Product Number
Description
Species Reactivity
Application
Monoclonal Anti-CYP3A4 antibody produced in mouse, clone 3H8, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
flow cytometry

immunofluorescence

immunohistochemistry

western blot
Anti-CYP3A4 antibody produced in mouse, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
Anti-CYP3A4 antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Anti-Cytochrome P450 Enzyme CYP3A4 Antibody, serum, Chemicon®,
Species Reactivity
human, mammals, pig, rat
Application
immunohistochemistry
western blot
Anti-CYP3A4 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
immunohistochemistry

western blot

Small Molecule - Inhibitor

Product Number
Description
Species
Piperine, ≥95%, FG,
Species
human
Piperine, ≥97%,
Species
human
Ivermectin, ,
Species
mouse, human
Erythromycin, meets USP testing specifications,
Species
mouse, human
Clotrimazole, ,
Species
mouse, human

Proteins

Product Number
Description
Species
CypExpress 3A4 Cytochrome P450 human, ,
Species
human
Cytochrome P450 human, 3A4 isozyme microsomes, with P450 reductase and cytochrome b5, recombinant, expressed in baculovirus infected insect cells (BTI-TN-5B1-4),
Species
human
Cytochrome P450 3A4 human, recombinant, expressed in E. coli,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human CYP3A4,
Species
human