ESR1
estrogen receptor 1
ER, ESR, ESRA, ESTRR, Era, NR3A1
Human ESR1 (2099), Mouse Esr1 (13982), Rat Esr1 (24890), domestic cat ESR1 (552888), dog ESR1 (403640), chicken ESR1 (396099), Thale Cress ESR1 (837856), Horse ESR1 (791249), Zebrafish esr1 (259252), cow ESR1 (407238) ...More
- Human(2099) Summary: This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters. [provided by RefSeq, Jul 2008]
- Mouse(13982) estrogen receptor 1 (alpha)
- Rat(24890) estrogen receptor 1
- domestic cat(552888) estrogen receptor 1
- dog(403640) estrogen receptor 1
- chicken(396099) estrogen receptor 1
- Thale Cress(837856) ethylene-responsive transcription factor ESR1
- Horse(791249) estrogen receptor 1
- Zebrafish(259252) estrogen receptor 1
- cow(407238) estrogen receptor 1
- Goat(100860768) estrogen receptor 1
- sheep(443228) estrogen receptor 1
- domestic guinea pig(100713276) estrogen receptor 1
Custom & Knockdown Gene Products
siRNA
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shRNA
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Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Small Molecule - Activator
Small Molecule - Agonist
Estrone solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
human
Small Molecule - Allosteric Modulator
Tamoxifen citrate for performance test, European Pharmacopoeia (EP) Reference Standard,
human
Small Molecule - Antagonist
Antibodies
Anti-ER alpha antibody, Rabbit Monoclonal, recombinant, expressed in HEK 293 cells, clone RM292, purified immunoglobulin,
human
immunohistochemistry
western blot
western blot
Anti-Estrogen-related Receptor α Antibody, Upstate®, from rabbit,
hamster, human, mouse, rat
electrophoretic mobility shift assay
immunohistochemistry
immunoprecipitation (IP)
western blot
immunohistochemistry
immunoprecipitation (IP)
western blot
ChIPAb+ Estrogen Receptor α - ChIP Validated Antibody and Primer Set, ascites fluid, from mouse,
human, mouse
ChIP
western blot
western blot
Anti-phospho-ESR1 (pSer104) antibody produced in rabbit, affinity isolated antibody,
human
immunohistochemistry
western blot
western blot
Small Molecule - Inhibitor
Small Molecule - Ligand
Small Molecule - Mixed Agonist/Antagonist
Proteins
Estrogen Receptor-α human, ≥80% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution,
human