MilliporeSigma

ESRRG

estrogen-related receptor gamma

Synonyms:
ERR3, ERRgamma, NR3B3
Species:
UniProtKB ID:
Gene ID:
  • Human(2104) Summary: This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region. [provided by RefSeq, Aug 2011]
  • Mouse(26381) estrogen-related receptor gamma
  • Rat(360896) estrogen-related receptor gamma
  • dog(478961) estrogen-related receptor gamma
  • domestic guinea pig(100719060) estrogen-related receptor gamma
  • naked mole-rat(101705764) estrogen-related receptor gamma
  • sheep(101102323) estrogen-related receptor gamma
  • Horse(100050530) estrogen-related receptor gamma
  • domestic cat(101091751) estrogen-related receptor gamma
  • cow(536732) estrogen-related receptor gamma
  • chicken(421357) estrogen-related receptor gamma

Custom & Knockdown Gene Products

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Small Molecule - Antagonist

Product Number
Description
Species
Diethylstilbestrol, ≥99% (HPLC),
Species
human, mouse, rat
(Z)-4-Hydroxytamoxifen, ≥98% Z isomer,
Species
human, rat
4-Hydroxytamoxifen, ≥70% Z isomer (remainder primarily E-isomer),
Species
human, rat
4-Hydroxytamoxifen, analytical standard, (E) and (Z) isomers (50:50),
Species
human, rat

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-ESRRG antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
Anti-ESRRG antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
Application
western blot
Anti-ESRRG antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
bovine, dog, hamster, horse, human, monkey, mouse, rabbit, rat
Application
ELISA
immunohistochemistry
Anti-ESRRG antibody produced in rabbit, IgG fraction of antiserum,
Species Reactivity
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
Application
immunohistochemistry
western blot
Anti-ESRRG Antibody, clone 2W3A9, Rabbit Monoclonal, ,
Species Reactivity
human, rat
Application
western blot

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human ESRRG,
Species
human
MISSION® esiRNA, targeting mouse Esrrg,
Species
mouse