MilliporeSigma

FKBP1A

FK506 binding protein 1A, 12kDa

Synonyms:
FKBP-12, FKBP-1A, FKBP1, FKBP12, PKC12, PKCI2, PPIASE
Species:
UniProtKB ID:
Gene ID:
  • Human(2280) Summary: The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed. [provided by RefSeq, Sep 2008]
  • Mouse(14225) FK506 binding protein 1a
  • Rat(25639) FK506 binding protein 1a
  • domestic guinea pig(100713967) FK506 binding protein 1A, 12kDa
  • chicken(374233) FK506 binding protein 1A, 12kDa
  • Domestic Rabbit(100328942) FK506 binding protein 1A, 12kDa
  • sheep(101105938) FK506 binding protein 1A, 12kDa
  • cow(614795) FK506 binding protein 1A, 12kDa
  • domestic cat(101100379) FK506 binding protein 1A, 12kDa
  • naked mole-rat(101702830) FK506 binding protein 1A, 12kDa
  • dog(100686033) FK506 binding protein 1A, 12kDa

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Antibodies

Product Number
Description
Species Reactivity
Application
ANTI-FKBP12 (CENTER) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
Anti-FKBP12 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
western blot
Monoclonal Anti-FKBP1A antibody produced in mouse, clone 1E5-A12, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
Anti-FKBP1A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
Tacrolimus solution, 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®,
Species
human
Everolimus solution, 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®,
Species
human
Tacrolimus, United States Pharmacopeia (USP) Reference Standard,
Species
human
Rapamycin from Streptomyces hygroscopicus, ≥95% (HPLC), powder,
Species
human
Pimecrolimus, ≥97% (HPLC),
Species
human

Proteins

Product Number
Description
Species
FKBP1a/FKBP12 human, recombinant, expressed in E. coli, ≥95% (SDS-PAGE),
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Fkbp1a,
Species
mouse
MISSION® esiRNA, targeting human FKBP1A,
Species
human