Skip to Content
MilliporeSigma

FURIN

furin (paired basic amino acid cleaving enzyme)

Synonyms:
FUR, PACE, PCSK3, SPC1
Species:
UniProtKB ID:
Gene ID:
  • Human(5045) Summary: The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease that can efficiently cleave precursor proteins at their paired basic amino acid processing sites. Some of its substrates are: proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene is thought to play a role in tumor progression. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(18550) furin (paired basic amino acid cleaving enzyme)
  • Rat(54281) furin (paired basic amino acid cleaving enzyme)
  • chicken(395457) furin (paired basic amino acid cleaving enzyme)
  • dog(488746) furin (paired basic amino acid cleaving enzyme)
  • domestic guinea pig(100733158) furin (paired basic amino acid cleaving enzyme)
  • domestic cat(101100308) furin (paired basic amino acid cleaving enzyme)
  • sheep(780454) furin (paired basic amino acid cleaving enzyme)
  • cow(281374) furin (paired basic amino acid cleaving enzyme)
  • Horse(100068931) furin (paired basic amino acid cleaving enzyme)
  • naked mole-rat(101717888) furin (paired basic amino acid cleaving enzyme)

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

ELISA

Product Number
Description
Species
Human Furin ELISA Kit, for serum, plasma, cell culture supernatant and urine,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-FURIN (N-terminal) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, canine, guinea pig, horse, human, mouse, rabbit, rat, zebrafish
Application
western blot
Anti-Furin Antibody, clone 16B1.1, clone 16B1.1, from mouse,
Species Reactivity
human
Application
western blot
Anti-FURIN antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
Anti-Furin Antibody, clone 1P6N8, Rabbit Monoclonal, ,
Species Reactivity
mouse
Application
immunoprecipitation (IP)
western blot

Proteins

Product Number
Description
Species
Furin human, ≥2,000 unit/mL, buffered aqueous solution, recombinant, expressed in baculovirus infected Sf9 cells,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Furin,
Species
mouse