MilliporeSigma

HTR2C

5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled

Synonyms:
5-HT2C, 5-HTR2C, HTR1C
Species:
UniProtKB ID:
Gene ID:
  • Human(3358) Summary: Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in humans have reported abnormalities in patterns of 5-HT2C editing in depressed suicide victims. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
  • Mouse(15560) 5-hydroxytryptamine (serotonin) receptor 2C
  • Rat(25187) 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
  • domestic cat(101099620) 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
  • naked mole-rat(101726296) 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
  • Horse(100057852) 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
  • cow(538909) 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
  • dog(450240) 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
  • chicken(428707) 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled

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Small Molecule - Agonist

Product Number
Description
Species
(±)-DOI hydrochloride, ≥98% (HPLC), solid,
Species
human
α-Methylserotonin maleate salt, ≥98% (HPLC),
Species
human
(R)(−)-DOI hydrochloride, ≥98% (HPLC), solid,
Species
human
Agomelatine, ≥98% (HPLC),
Species
human
Nortriptyline hydrochloride, ≥98% (HPLC), powder,
Species
human

Small Molecule - Allosteric Modulator

Product Number
Description
Species
DCEBIO, ≥98% (HPLC), solid,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
Cyclobenzaprine hydrochloride, European Pharmacopoeia (EP) Reference Standard,
Species
human
4-Benzylpiperidine, 99%,
Species
rat
Cyclobenzaprine hydrochloride, British Pharmacopoeia (BP) Reference Standard,
Species
human
1,2,3,4-Tetrahydro-9H-pyrido[3,4-b]indole, 98%,
Species
rat
Cyclobenzaprine hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-5-HT-2C antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence

immunohistochemistry
Anti-HTR2C antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot
Anti-Serotonin Receptor 2C/HTR2C antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
canine, human, mouse, rat
Application
ELISA
western blot

Small Molecule - Blocker

Product Number
Description
Species
Mianserin hydrochloride, ,
Species
human
Trazodone hydrochloride, ≥99% (HPLC), powder,
Species
human
Trimipramine maleate salt, ≥98% (TLC), powder,
Species
human
Zimelidine dihydrochloride, solid,
Species
human

Small Molecule - Inhibitor

Product Number
Description
Species
Trazodone hydrochloride, United States Pharmacopeia (USP) Reference Standard,
Species
human
Trazodone hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®,
Species
human
Trazodone hydrochloride, British Pharmacopoeia (BP) Reference Standard,
Species
human
Trazodone hydrochloride impurity standard, British Pharmacopoeia (BP) Reference Standard,
Species
human
Nefazodone hydrochloride, United States Pharmacopeia (USP) Reference Standard,
Species
human

Small Molecule - Ligand

Product Number
Description
Species
Nω-Methyl-5-hydroxy­trypt­amine oxalate salt, ≥90% (HPLC),
Species
human

Small Molecule - Metabolite

Product Number
Description
Species
5-Hydroxyindole-3-acetic acid, ≥98% (HPLC), crystalline,
Species
human

Small Molecule - Mixed Agonist/Antagonist

Product Number
Description
Species
Mifepristone, ≥98%,
Species
human, mouse, rat
Haloperidol, powder,
Species
human, rat
Clozapine, ,
Species
human, rat

Small Molecule - Precursor

Product Number
Description
Species
5-Hydroxy-L-tryptophan, powder,
Species
human

Proteins

Product Number
Description
Species
ChemiSCREEN Human 5-HT2C Receptor Membrane Preparation, Human 5-HT2C GPCR membrane preparation for Radioligand binding Assays & GTPγS binding.,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human HTR2C,
Species
human