MilliporeSigma

IDH1

isocitrate dehydrogenase 1 (NADP+), soluble

Synonyms:
IDCD, IDH, IDP, IDPC, PICD
Species:
UniProtKB ID:
Gene ID:
  • Human(3417) Summary: Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. [provided by RefSeq, Jul 2008]
  • Mouse(15926) isocitrate dehydrogenase 1 (NADP+), soluble
  • Rat(24479) isocitrate dehydrogenase 1 (NADP+), soluble
  • dog(478889) isocitrate dehydrogenase 1 (NADP+), soluble
  • Zebrafish(100006589) isocitrate dehydrogenase 1 (NADP+), soluble
  • Thale Cress(829679) Isocitrate dehydrogenase [NAD] regulatory subunit 1
  • domestic guinea pig(100729107) isocitrate dehydrogenase 1 (NADP+), soluble
  • chicken(424112) isocitrate dehydrogenase 1 (NADP+), soluble
  • Domestic Rabbit(100328559) isocitrate dehydrogenase 1 (NADP+), soluble
  • sheep(443257) isocitrate dehydrogenase 1 (NADP+), soluble
  • cow(281235) isocitrate dehydrogenase 1 (NADP+), soluble
  • Horse(100066416) isocitrate dehydrogenase 1 (NADP+), soluble
  • domestic cat(751618) isocitrate dehydrogenase 1 (NADP+), soluble
  • naked mole-rat(101705662) isocitrate dehydrogenase 1 (NADP+), soluble

Custom & Knockdown Gene Products

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-IDH1 (ab1) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat, sheep
Application
immunohistochemistry
western blot
Anti-Isocitrate Dehydrogenase 1 (IDH1)-R132H Antibody, clone HMab-1, clone HMab-1, from mouse,
Species Reactivity
human
Application
immunocytochemistry
immunohistochemistry

western blot
Anti-IDH1 Antibody, clone 12D6.1, clone 12D6.1, from mouse,
Species Reactivity
human
Application
immunohistochemistry
western blot
Monoclonal Anti-IDH1 antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL0219, purified immunoglobulin, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry

western blot
Anti-IDH1 (R132H) antibody, Mouse monoclonal, clone HMab-1, purified from hybridoma cell culture,
Species Reactivity
human
Application
western blot

Kits

Product Number
Description
Species
IDH Activity Assay Kit, sufficient for 100 colorimetric tests,
Species
mouse, rat, human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human IDH1,
Species
human
MISSION® esiRNA, targeting mouse Idh1,
Species
mouse