MilliporeSigma

IL12RB2

interleukin 12 receptor, beta 2

Synonyms:
Species:
UniProtKB ID:
Gene ID:
  • Human(3595) Summary: The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene. [provided by RefSeq, Apr 2012]
  • Mouse(16162) interleukin 12 receptor, beta 2
  • Rat(171334) interleukin 12 receptor, beta 2
  • naked mole-rat(101717608) interleukin 12 receptor, beta 2
  • domestic guinea pig(100722774) interleukin 12 receptor, beta 2
  • Domestic Rabbit(100350416) interleukin 12 receptor, beta 2
  • sheep(100820736) interleukin 12 receptor, beta 2
  • cow(282452) interleukin 12 receptor, beta 2
  • dog(489550) interleukin 12 receptor, beta 2
  • domestic cat(101088012) interleukin 12 receptor, beta 2
  • chicken(424705) interleukin 12 receptor, beta 2
  • Zebrafish(100134971) interleukin 12 receptor, beta 2a

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

ELISA

Product Number
Description
Species
Human IL-12 R beta 2 ELISA, for serum, plasma and cell culture supernatants,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-IL12RB2 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, canine, guinea pig, horse, human, mouse, pig, rabbit, sheep
Application
western blot
Anti-IL12RB2 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Anti-IL12RB2 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human IL12RB2,
Species
human