MilliporeSigma

NPC1L1

NPC1-like 1

Synonyms:
NPC11L1
Species:
UniProtKB ID:
Gene ID:
  • Human(29881) Summary: The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up free cholesterol into cells through vesicular endocytosis and plays a critical role in the absorption of intestinal cholesterol. It also has the ability to transport alpha-tocopherol (vitamin E). The drug ezetimibe targets this protein and inhibits the absorption of intestinal cholesterol and alpha-tocopherol. In addition, this protein may play a critical role in regulating lipid metabolism. Polymorphic variations in this gene are associated with plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) risk. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
  • Mouse(237636) NPC1-like 1
  • Rat(432367) NPC1-like 1
  • cow(539550) NPC1-like 1
  • naked mole-rat(101718169) NPC1-like 1
  • domestic guinea pig(100716804) NPC1-like 1
  • Domestic Rabbit(100009042) NPC1 (Niemann-Pick disease, type C1, gene)-like 1
  • sheep(101118355) NPC1-like 1
  • dog(610398) NPC1 (Niemann-Pick disease, type C1, gene)-like 1
  • domestic cat(101099108) NPC1 (Niemann-Pick disease, type C1, gene)-like 1
  • Zebrafish(100616532) NPC1 (Niemann-Pick disease, type C1, gene)-like 1

Custom & Knockdown Gene Products

  • siRNA

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  • Custom Gene Products

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Antibodies

Product Number
Description
Species Reactivity
Application
ANTI-NPC1L1(N-TERMINAL) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
western blot

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Npc1l1,
Species
mouse
MISSION® esiRNA, targeting human NPC1L1,
Species
human