MilliporeSigma

NR1H3

nuclear receptor subfamily 1, group H, member 3

Synonyms:
LXR-a, LXRA, RLD-1
Species:
UniProtKB ID:
Gene ID:
  • Human(10062) Summary: The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
  • Mouse(22259) nuclear receptor subfamily 1, group H, member 3
  • Rat(58852) nuclear receptor subfamily 1, group H, member 3
  • chicken(395221) nuclear receptor subfamily 1, group H, member 3
  • Zebrafish(548341) nuclear receptor subfamily 1, group H, member 3
  • naked mole-rat(101709627) nuclear receptor subfamily 1, group H, member 3
  • domestic guinea pig(100725013) nuclear receptor subfamily 1, group H, member 3
  • Goat(100860906) nuclear receptor subfamily 1, group H, member 3
  • sheep(101116762) nuclear receptor subfamily 1, group H, member 3
  • cow(507176) nuclear receptor subfamily 1, group H, member 3
  • domestic cat(101092889) nuclear receptor subfamily 1, group H, member 3
  • dog(483625) nuclear receptor subfamily 1, group H, member 3

Custom & Knockdown Gene Products

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Small Molecule - Agonist

Product Number
Description
Species
Hyodeoxycholic acid, ≥98%,
Species
human
T0901317, ≥98%,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-NR1H3 antibody produced in rabbit, IgG fraction of antiserum,
Species Reactivity
human
Application
western blot
Anti-NR1H3 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
Anti-NR1H3 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
immunofluorescence
western blot
Anti-LXR-A antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence

immunohistochemistry

western blot
Anti-LXR alpha Antibody, clone 2B7, clone 2B7, from mouse,
Species Reactivity
mouse, rat
Application
immunoprecipitation (IP)
western blot

Small Molecule - Mixed Agonist/Antagonist

Product Number
Description
Species
T0901317, ≥98%,
Species
human

Proteins

Product Number
Description
Species
LXR, α human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE),
Species
human
LXR, α, ligand binding domain, GST tagged human, recombinant, expressed in E. coli, ≥80% (SDS-PAGE),
Species
human
LXRα-ligand binding domain (215-667) human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE),
Species
human
LXR, α isoform, N-terminal region (1-182), GST tagged β human, recombinant, expressed in E. coli, ≥80% (SDS-PAGE),
Species
human
LXR, α isoform, GST tagged human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE),
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Nr1h3,
Species
mouse
MISSION® esiRNA, targeting human NR1H3,
Species
human