MilliporeSigma

NR1I2

nuclear receptor subfamily 1, group I, member 2

Synonyms:
BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR
Species:
UniProtKB ID:
Gene ID:
  • Human(8856) Summary: This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq, Jul 2008]
  • Mouse(18171) nuclear receptor subfamily 1, group I, member 2
  • Rat(84385) nuclear receptor subfamily 1, group I, member 2
  • sheep(101118075) nuclear receptor subfamily 1, group I, member 2
  • cow(493713) nuclear receptor subfamily 1, group I, member 2
  • domestic cat(101088355) nuclear receptor subfamily 1, group I, member 2
  • dog(403482) nuclear receptor subfamily 1, group I, member 2
  • Zebrafish(565875) nuclear receptor subfamily 1, group I, member 2
  • naked mole-rat(101722589) nuclear receptor subfamily 1, group I, member 2
  • domestic guinea pig(100719967) nuclear receptor subfamily 1, group I, member 2

Custom & Knockdown Gene Products

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  • Custom Gene Products

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-NR1I2 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human, rat
Application
immunofluorescence
western blot
Anti-NR1I2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
Anti-NR1I2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
Anti-NR1I2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
Anti-PXR Antibody, clone 1F10.1, clone 1F10.1, from mouse,
Species Reactivity
chimpanzee, gorilla, human
Application
western blot

Cell Lines

Product Number
Description
Species
PXR Knockout HepaRG Cells, 1 vial,
Species

Proteins

Product Number
Description
Species
Pregnane X receptor (138-434), His tagged human, recombinant, expressed in E. coli, ≥85% (SDS-PAGE),
Species
human
Pregnane X Receptor human, recombinant, expressed in insect cells, ≥80% (SDS-PAGE),
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human NR1I2,
Species
human