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PIK3R1

phosphoinositide-3-kinase, regulatory subunit 1 (alpha)

Synonyms:
AGM7, GRB1, p85, p85-ALPHA
Species:
UniProtKB ID:
Gene ID:
  • Human(5295) Summary: Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]
  • Mouse(18708) phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
  • Rat(25513) phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
  • domestic guinea pig(100730242) phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
  • domestic cat(100271864) phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
  • cow(282307) phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
  • sheep(101121455) phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
  • chicken(427171) phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
  • Zebrafish(557176) phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha)
  • dog(487235) phosphoinositide-3-kinase, regulatory subunit 1 (alpha)

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-PI3-kinase p85-α antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence

immunohistochemistry

western blot
Anti-phospho-PI3-kinase p85-α/γ (pTyr467/199) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence

western blot
Anti-phospho-PI3-kinase p85-α (pTyr607) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry

western blot
Monoclonal Anti-PIK3R1 antibody produced in mouse, clone 1C10, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human, mouse
Application
ELISA
proximity ligation assay

western blot
Anti-PI3K P85 antibody, Rabbit monoclonal, clone SP62, recombinant, expressed in proprietary host, affinity isolated antibody,
Species Reactivity
bovine, frog, human, mouse, rat
Application
flow cytometry
immunohistochemistry

Small Molecule - Inhibitor

Product Number
Description
Species
Wortmannin, Ready Made Solution, from Penicillium funiculosum, ≥95% (HPLC),
Species
human
Wortmannin, from Penicillium funiculosum, ≥98% (HPLC and TLC),
Species
human
Diphenyleneiodonium chloride, ≥98%,
Species
mouse, human
PF-04691502, ≥98% (HPLC),
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human PIK3R1,
Species
human
MISSION® esiRNA, targeting mouse Pik3r1,
Species
mouse