MilliporeSigma

POMC

proopiomelanocortin

Synonyms:
ACTH, CLIP, LPH, MSH, NPP, POC
Species:
UniProtKB ID:
Gene ID:
  • Human(5443) Summary: This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
  • Mouse(18976) pro-opiomelanocortin-alpha
  • Rat(24664) proopiomelanocortin
  • cow(281416) proopiomelanocortin
  • domestic guinea pig(100720803) proopiomelanocortin
  • chicken(422011) proopiomelanocortin
  • naked mole-rat(101718053) proopiomelanocortin
  • Goat(100861398) proopiomelanocortin
  • Horse(100071524) proopiomelanocortin
  • domestic cat(101087223) proopiomelanocortin
  • sheep(443212) proopiomelanocortin
  • dog(403659) proopiomelanocortin

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Antibodies

Product Number
Description
Species Reactivity
Application
Monoclonal Anti-beta Endorphin antibody produced in mouse, clone B31.15,
Species Reactivity
human
Application
immunohistochemistry
Anti-Melanocyte Stimulating Hormone α Antibody, serum, Chemicon®,
Species Reactivity
mammals
Application
immunohistochemistry
radioimmunoassay
Anti-α-MSH antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
microarray
Anti-Proopiomelanocortin/POMC antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry

western blot
Anti-POMC antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot

Proteins

Product Number
Description
Species
α-Melanocyte stimulating hormone, ≥97% (HPLC),
Species
human
Adrenocorticotropic Hormone Fragment 7-38 human, ≥97% (HPLC),
Species
human
β-Endorphin rat, ≥97% (HPLC),
Species
rat
β-Endorphin human, ≥95% (HPLC),
Species
human
Adrenocorticotropic Hormone human, ≥97% (HPLC),
Species
human