MilliporeSigma

POMC

proopiomelanocortin

Synonyms:
ACTH, CLIP, LPH, MSH, NPP, POC
Species:
UniProtKB ID:
Gene ID:
  • Human(5443) Summary: This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
  • Mouse(18976) pro-opiomelanocortin-alpha
  • Rat(24664) proopiomelanocortin
  • cow(281416) proopiomelanocortin
  • domestic guinea pig(100720803) proopiomelanocortin
  • chicken(422011) proopiomelanocortin
  • naked mole-rat(101718053) proopiomelanocortin
  • Goat(100861398) proopiomelanocortin
  • Horse(100071524) proopiomelanocortin
  • domestic cat(101087223) proopiomelanocortin
  • sheep(443212) proopiomelanocortin
  • dog(403659) proopiomelanocortin

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-POMC antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Anti-POMC antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunohistochemistry
Anti-Endorphin β Antibody, clone 3-E7, clone 3-E7, Chemicon®, from mouse,
Species Reactivity
human, pig
Application
ELISA
immunohistochemistry
Anti-POMC antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunohistochemistry
Anti-Melanocyte Stimulating Hormone α Antibody, serum, Chemicon®,
Species Reactivity
mammals
Application
immunohistochemistry
radioimmunoassay

Proteins

Product Number
Description
Species
Acetyl-[Nle4, Asp5, D-2-Nal7, Lys10]-cyclo-α-Melanocyte Stimulating Hormone Amide Fragment 4-10, ≥95% (HPLC),
Species
human
[D-Lys16]-Adrenocorticotropic Hormone Fragment 1-24 human, rat trifluoroacetate salt, ≥95% (HPLC), solid,
Species
human
Adrenocorticotropic Hormone rat, ≥95% (HPLC),
Species
rat
[Nle4, D-Phe7]-α-Melanocyte Stimulating Hormone trifluoroacetate salt, ≥95% (HPLC),
Species
human
Adrenocorticotropic Hormone Fragment 7-38 human, ≥97% (HPLC),
Species
human