MilliporeSigma

PSMC1

proteasome (prosome, macropain) 26S subunit, ATPase, 1

Synonyms:
P26S4, S4, p56
Species:
UniProtKB ID:
Gene ID:
  • Human(5700) Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit and a 20S core alpha subunit interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. This subunit also interacts with the adenovirus E1A protein and this interaction alters the activity of the proteasome. Finally, this subunit interacts with ataxin-7, suggesting a role for the proteasome in the development of spinocerebellar ataxia type 7, a progressive neurodegenerative disorder. [provided by RefSeq, Jul 2008]
  • Mouse(19179) protease (prosome, macropain) 26S subunit, ATPase 1
  • Rat(117263) proteasome (prosome, macropain) 26S subunit, ATPase, 1
  • Horse(100062573) proteasome (prosome, macropain) 26S subunit, ATPase, 1
  • chicken(395804) proteasome (prosome, macropain) 26S subunit, ATPase, 1
  • domestic guinea pig(100733985) proteasome (prosome, macropain) 26S subunit, ATPase, 1
  • naked mole-rat(101698658) proteasome (prosome, macropain) 26S subunit, ATPase, 1
  • sheep(101120165) proteasome (prosome, macropain) 26S subunit, ATPase, 1
  • domestic cat(101094025) proteasome (prosome, macropain) 26S subunit, ATPase, 1
  • cow(506238) proteasome (prosome, macropain) 26S subunit, ATPase, 1
  • dog(100688636) proteasome (prosome, macropain) 26S subunit, ATPase, 1

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-PSMC1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
immunohistochemistry

western blot
Anti-PSMC1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry

western blot
Anti-PSMC1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
Application
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
Z-Leu-Leu-Norvalinal, ≥90% (HPLC), powder,
Species
rat, mouse, human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Psmc1,
Species
mouse