MilliporeSigma

PTEN

phosphatase and tensin homolog

Synonyms:
10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1
Species:
UniProtKB ID:
Gene ID:
  • Human(5728) Summary: This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq, Jul 2008]
  • Mouse(19211) phosphatase and tensin homolog
  • Rat(50557) phosphatase and tensin homolog
  • fruit fly(43991) CG5671 gene product from transcript CG5671-RB
  • naked mole-rat(101714930) phosphatase and tensin homolog
  • domestic guinea pig(100723659) phosphatase and tensin homolog
  • sheep(101119351) phosphatase and tensin homolog
  • cow(540786) phosphatase and tensin homolog
  • domestic cat(101091813) phosphatase and tensin homolog
  • dog(403832) phosphatase and tensin homolog
  • chicken(423675) phosphatase and tensin homolog

Custom & Knockdown Gene Products

  • siRNA

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  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-PTEN antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
western blot
Anti-Phospho-PTEN-S370 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-PTEN Antibody, clone A2b1 ZooMAb® Mouse Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
bovine, canine, feline, human, monkey, mouse, porcine, rat
Application
immunocytochemistry
immunohistochemistry

western blot
Anti-PTEN Antibody, clone 6H2.1 ZooMAb® Mouse Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human, mouse, rat
Application
immunocytochemistry
immunohistochemistry

western blot
Anti-PTEN (Ab-370) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot

Cell Lines

Product Number
Description
Species
MCF10A CELLS PTEN (-/-), ,
Species
human
DLD1 Cells PTEN -/-, ,
Species
human
SW48 Cells PTEN -/-, ,
Species
human
MCF10A CELLS PTEN (-/-) PIK3CA H1047R (+/-), ,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, ,
Species
mouse
MISSION® esiRNA, targeting human PTEN,
Species
human