MilliporeSigma

PTPN1

protein tyrosine phosphatase, non-receptor type 1

Synonyms:
PTP1B
Species:
UniProtKB ID:
Gene ID:
  • Human(5770) Summary: The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
  • Mouse(19246) protein tyrosine phosphatase, non-receptor type 1
  • Rat(24697) protein tyrosine phosphatase, non-receptor type 1
  • chicken(395688) protein tyrosine phosphatase, non-receptor type 1
  • Zebrafish(30081) protein tyrosine phosphatase, non-receptor type 1
  • cow(508658) protein tyrosine phosphatase, non-receptor type 1
  • Domestic Rabbit(100354834) protein tyrosine phosphatase, non-receptor type 1
  • Horse(100052066) protein tyrosine phosphatase, non-receptor type 1
  • domestic cat(101099626) protein tyrosine phosphatase, non-receptor type 1
  • dog(477263) protein tyrosine phosphatase, non-receptor type 1
  • naked mole-rat(101696680) protein tyrosine phosphatase, non-receptor type 1
  • domestic guinea pig(100730699) protein tyrosine phosphatase, non-receptor type 1
  • sheep(101118209) protein tyrosine phosphatase, non-receptor type 1

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ELISA

Product Number
Description
Species
Human PTP1B ELISA, for serum, plasma and cell culture supernatants,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
ANTI-PTP1B antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human, mouse
Application
western blot
ANTI-PTP1B (N-TERMINAL) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Anti-PTPN1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, guinea pig, horse, human, mouse, rat
Application
western blot
Anti-PTPN1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry

western blot
Anti-PTP1B antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry

western blot

Small Molecule - Inhibitor

Product Number
Description
Species
Chromone-3-carboxylic acid, 97%,
Species
human
2,6-Naphthalenedicarboxylic acid, 95%,
Species
human
2,6-Naphthalenedicarboxylic acid, 99%,
Species
human
6-Bromo-3-formylchromone, 99%,
Species
human
2-Amino-3-formylchromone, 97%,
Species
human

Kits

Product Number
Description
Species
PTP Assay Kit 1, PTP Assay Kit 1 can be used to detect PTP-1B activity by dephosphorylation of the phosphopeptide (RRLIEDAEpYAARG) using malachite green detection, or by hydrolysis of pNPP.,
Species
human

Proteins

Product Number
Description
Species
Protein Tyrosine Phosphatase 1B human, recombinant, expressed in E. coli,
Species
human
PTP1B (1-321)/PTPN1 Active from mouse, recombinant, expressed in E. coli, ≥90% (SDS-PAGE),
Species
human
PTP1B full length Active human, recombinant, expressed in E. coli, ≥55% (SDS-PAGE), aqueous solution,
Species
human
PTP1B (1-321)/PTPN1 Active human, recombinant, expressed in E. coli, ≥90% (SDS-PAGE),
Species
human
PTPN1, active, GST tagged human, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Ptpn1,
Species
mouse
MISSION® esiRNA, targeting human PTPN1,
Species
human