MilliporeSigma

PTPRJ

protein tyrosine phosphatase, receptor type, J

Synonyms:
CD148, DEP1, HPTPeta, R-PTP-ETA, SCC1
Species:
UniProtKB ID:
Gene ID:
  • Human(5795) Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(19271) protein tyrosine phosphatase, receptor type, J
  • Rat(29645) protein tyrosine phosphatase, receptor type, J
  • chicken(395330) protein tyrosine phosphatase, receptor type, J
  • Domestic Rabbit(100347798) protein tyrosine phosphatase, receptor type, J
  • domestic cat(101086598) protein tyrosine phosphatase, receptor type, J
  • dog(483617) protein tyrosine phosphatase, receptor type, J
  • Horse(100058689) protein tyrosine phosphatase, receptor type, J
  • cow(508150) protein tyrosine phosphatase, receptor type, J
  • sheep(101121292) protein tyrosine phosphatase, receptor type, J
  • domestic guinea pig(100729887) protein tyrosine phosphatase, receptor type, J
  • naked mole-rat(101726039) protein tyrosine phosphatase, receptor type, J

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

ELISA

Product Number
Description
Species
Human DEP-1 ELISA, for serum, plasma and cell culture supernatants,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Monoclonal Anti-CD148-APC antibody produced in mouse, clone MEM-CD148/05,
Species Reactivity
Application
flow cytometry
Monoclonal Anti-CD148 antibody produced in mouse, clone MEM-CD148/05, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
flow cytometry
Anti-Protein-tyrosine phosphatase eta (CD148) Antibody, clone 8A-1, clone 8A-1, from hamster(Syrian),
Species Reactivity
mouse
Application
flow cytometry
immunohistochemistry

western blot
Anti-PTPRJ antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-CD148/DEP-1 Antibody, clone Ab1 (Azide Free), clone Ab 1, from mouse,
Species Reactivity
human, mouse
Application
immunohistochemistry
immunoprecipitation (IP)

inhibition assay

western blot

Proteins

Product Number
Description
Species
DEP1 Active human, recombinant, expressed in E. coli, ≥90% (SDS-PAGE),
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Ptprj,
Species
mouse
MISSION® esiRNA, targeting human PTPRJ,
Species
human