MilliporeSigma

SESN1

sestrin 1

Synonyms:
PA26, SEST1
Species:
UniProtKB ID:
Gene ID:
  • Human(27244) Summary: This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
  • Mouse(140742) sestrin 1
  • Rat(294518) sestrin 1
  • domestic cat(101099380) sestrin 1
  • cow(538226) sestrin 1
  • sheep(101115970) sestrin 1
  • dog(481956) sestrin 1
  • Zebrafish(436933) sestrin 1
  • naked mole-rat(101699483) sestrin 1
  • chicken(421766) sestrin 1
  • domestic guinea pig(100713452) sestrin 1

Custom & Knockdown Gene Products

  • siRNA

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  • Custom Gene Products

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-sestrin 1 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
Anti-SESN1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
Anti-SESN1 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Anti-SESN1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
Application
western blot

Proteins

Product Number
Description
Species
Sestrin 1 human, recombinant, expressed in baculovirus infected Sf9 cells, ≥44% (SDS-PAGE),
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Sesn1,
Species
mouse
MISSION® esiRNA, targeting human SESN1,
Species
human