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SLC12A1

solute carrier family 12 (sodium/potassium/chloride transporter), member 1

Synonyms:
BSC1, NKCC2
Species:
UniProtKB ID:
Gene ID:
  • Human(6557) Summary: This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven.[provided by RefSeq, May 2010]
  • Mouse(20495) solute carrier family 12, member 1
  • Rat(25065) solute carrier family 12 (sodium/potassium/chloride transporter), member 1
  • Domestic Rabbit(100328575) solute carrier family 12 (sodium/potassium/chloride transporters), member 1
  • sheep(101111371) solute carrier family 12 (sodium/potassium/chloride transporters), member 1
  • domestic guinea pig(100716647) solute carrier family 12 (sodium/potassium/chloride transporters), member 1
  • naked mole-rat(101719170) solute carrier family 12 (sodium/potassium/chloride transporters), member 1
  • chicken(415433) solute carrier family 12 (sodium/potassium/chloride transporters), member 1
  • Zebrafish(100329975) solute carrier family 12, member 1
  • dog(478292) solute carrier family 12 (sodium/potassium/chloride transporters), member 1
  • domestic cat(101100216) solute carrier family 12 (sodium/potassium/chloride transporters), member 1
  • cow(407161) solute carrier family 12 (sodium/potassium/chloride transporters), member 1

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

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  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Antibodies

Product Number
Description
Species Reactivity
Application
Monoclonal Anti-SLC12A1 antibody produced in mouse, clone 4H4, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
Anti-SLC12A1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-SLC12A1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
Anti-SLC12A1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, horse, human, mouse, pig, rabbit, rat
Application
immunohistochemistry
western blot
Anti-SLC12A1 antibody produced in rabbit, 1 mg/mL, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
Torasemide for system suitability, European Pharmacopoeia (EP) Reference Standard,
Species
human
Etacrynic acid for system suitability, European Pharmacopoeia (EP) Reference Standard,
Species
human
Bumetanide, ≥98%,
Species
human
Torsemide, ≥98% (HPLC), solid,
Species
human
Furosemide, United States Pharmacopeia (USP) Reference Standard,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Slc12a1,
Species
mouse
MISSION® esiRNA, targeting human SLC12A1,
Species
human