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SMAD4

SMAD family member 4

Synonyms:
DPC4, JIP, MADH4, MYHRS
Species:
UniProtKB ID:
Gene ID:
  • Human(4089) Summary: This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome. [provided by RefSeq, Oct 2009]
  • Mouse(17128) SMAD family member 4
  • Rat(50554) SMAD family member 4
  • dog(476196) SMAD family member 4
  • domestic cat(101093650) SMAD family member 4
  • Zebrafish(30640) MAD homolog 4 (Drosophila)
  • domestic guinea pig(100717853) SMAD family member 4
  • naked mole-rat(101703764) SMAD family member 4
  • sheep(443171) SMAD family member 4
  • cow(540248) SMAD family member 4
  • Horse(100033846) SMAD family member 4
  • Goat(100861019) SMAD family member 4

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ELISA

Product Number
Description
Species
Human Smad4 ELISA, for serum, plasma and cell culture supernatants,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Monoclonal Anti-SMAD4 antibody produced in mouse, clone 4G1C6, ascites fluid,
Species Reactivity
human
Application
ELISA
flow cytometry

immunofluorescence

immunohistochemistry

western blot
Monoclonal Anti-SMAD4 antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL9774, purified immunoglobulin, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
Anti-Smad4/DPC4 Antibody, from rabbit, purified by affinity chromatography,
Species Reactivity
chimpanzee, human, mouse, rat
Application
immunocytochemistry
western blot
Anti-SMAD4 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, goat, guinea pig, horse, human, mouse, rabbit, rat, sheep
Application
immunohistochemistry
western blot
Anti-SMAD4 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human, mouse
Application
immunofluorescence
immunohistochemistry

western blot

Cell Lines

Product Number
Description
Species
SW48 Cells SMAD4 -/-, ,
Species
human
A549 Cells SMAD4 -/-, ,
Species
human
DLD1 Cells SMAD4 -/-, ,
Species
human
A549 Cells GFP-SMAD4, ,
Species
human

Proteins

Product Number
Description
Species
SMAD4, GST tagged human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Smad4,
Species
mouse
MISSION® esiRNA, targeting human SMAD4,
Species
human