MilliporeSigma

TRPV1

transient receptor potential cation channel, subfamily V, member 1

Synonyms:
VR1
Species:
UniProtKB ID:
Gene ID:
  • Human(7442) Summary: Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(193034) transient receptor potential cation channel, subfamily V, member 1
  • Rat(83810) transient receptor potential cation channel, subfamily V, member 1
  • domestic cat(101093406) transient receptor potential cation channel, subfamily V, member 1
  • chicken(395259) transient receptor potential cation channel, subfamily V, member 1
  • naked mole-rat(101720480) transient receptor potential cation channel, subfamily V, member 1
  • Domestic Rabbit(100008926) transient receptor potential cation channel, subfamily V, member 1
  • domestic cat(100303454) transient receptor potential cation channel, subfamily V, member 1
  • Zebrafish(561195) transient receptor potential cation channel, subfamily V, member 1
  • cow(539074) transient receptor potential cation channel, subfamily V, member 1
  • domestic guinea pig(100135466) transient receptor potential cation channel, subfamily V, member 1
  • Horse(100034158) transient receptor potential cation channel, subfamily V, member 1
  • sheep(101110158) transient receptor potential cation channel, subfamily V, member 1
  • dog(445457) transient receptor potential cation channel, subfamily V, member 1

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Small Molecule - Agonist

Product Number
Description
Species
Dihydrocapsaicin, from Capsicum sp., ≥85%,
Species
rat, human
N-Vanillylnonanamide, ≥97%, powder,
Species
rat
N-Oleoylethanolamine, ~98% (TLC),
Species
human, mouse, rat

Small Molecule - Antagonist

Product Number
Description
Species
SB-366791, ≥98% (HPLC), powder,
Species
human
6-Iodonordihydrocapsaicin, ≥98% (HPLC), solid,
Species
human
Capsazepine, ≥98% (HPLC), solid,
Species
human, rat
Capsaicin, from Capsicum sp., ≥50% (HPLC),
Species
rat, human
Capsaicin, ≥95%, from Capsicum sp.,
Species
rat, human

Antibodies

Product Number
Description
Species Reactivity
Application
Monoclonal Anti-TRPV1 antibody produced in mouse, clone 1F5, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
Monoclonal Anti-TRPV1 antibody produced in mouse, clone 1A8, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
Anti-Vanilloid Receptor-1 antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
rat
Application
microarray
western blot
Anti-TRPV1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
ELISA
western blot
Anti-TRPV1 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
Olvanil, powder,
Species
human
Acetaminophen, United States Pharmacopeia (USP) Reference Standard,
Species
human
Paracetamol, British Pharmacopoeia (BP) Reference Standard,
Species
human
Paracetamol for equipment qualification, European Pharmacopoeia (EP) Reference Standard,
Species
human
Capsaicin, from Capsicum sp., ≥50% (HPLC),
Species
rat, human

Small Molecule - Mixed Agonist/Antagonist

Product Number
Description
Species
N-Vanillylnonanamide, ≥97%, powder,
Species
rat
Capsazepine, ≥98% (HPLC), solid,
Species
human, rat

Small Molecule - Opener

Product Number
Description
Species
Capsaicin, phyproof® Reference Substance,
Species
human
Capsaicin, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human
Capsaicin, European Pharmacopoeia (EP) Reference Standard,
Species
human
Capsaicin, analytical standard,
Species
human
Capsaicin, United States Pharmacopeia (USP) Reference Standard,
Species
human

Proteins

Product Number
Description
Species
Capsaicin Receptor Control Peptide for AB5889, ,
Species
rat

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Trpv1,
Species
mouse
MISSION® esiRNA, targeting human TRPV1,
Species
human