MilliporeSigma

Target Identification for Antibody Drug Discovery

Identify targets using the most comprehensive set
of genome-wide screening tools available.

HomeIntegrated OfferingsMonoclonal Antibodies (mAbs)Antibody Drug DiscoveryTherapeutic Antibody Target DiscoveryTools for Target Identification and Validation

 

Target discovery involves the identification of specific genes or proteins that play a key role in disease. We offer a complete set of genome-modifying screening tools, including CRISPR and shRNA modalities, to facilitate target identification for monoclonal antibody screening. These tools can be combined with a wide array of cellular and biochemical tools to fast-track target validation and therapeutic development. 

Tools for Target Identification and Validation

Functional Genomics Screening Tools for Target Identification

3D illustration of a double-stranded DNA strand in white, with a section in light pink cut out

Identify novel therapeutic targets using the most complete set of genome-wide functional genomics screening tools available. 

In vitro Tools for Target Validation

Developing cellular assays for lead discovery requires the production of biologically relevant models for comprehensive assessment. Our premier in vitro solutions include assays, reagents, and cell culture tools designed to help researchers validate their screened targets and identify phenotypes. We provide a comprehensive range of disease-relevant cell lines to enable the development of tissue-specific models for drug screening. Our organoid portfolio includes both iPSC- and patient-derived organoids, enabling drug screening in highly biomimetic models supported by specialized media, reagents, and 3D cell culture plates. Maximize your lead discovery with our MultiScreen® HTS plates or use our Millicell® cell culture inserts and plates to create scalable 6-, 12-, 24-, or 96-well cell assay environments. Our immunoassay platform solutions and western blotting tools enable sensitive qualitative or quantitative detection of biomarkers on any scale.


Related Categories

Microscopic image of fluorescently-stained mammalian cells
Mammalian Cell Lines

ECACC repository cell lines, cancer cell lines, cellular models, and more.

Blood, patient tumor xenografts, and hepatocytes for drug screening and ADME/tox
Primary Cells

Human primary cells, normal and disease state PBMCs, and immune cells.

Microscopic image of fluorescently-stained human colon organoids
Organoids

Human iPSC-derived and patient-derived organoids for advanced cell culture.

A scientist’s hand using tweezers to place a Millicell® cell culture insert containing culture media into a microplate
Millicell® Cell Culture Inserts

Promoting natural, multidimensional growth for more relevant in vitro models.

Cells stained with CellVue® Claret far red membrane label
Live Cell Imaging Reagents

Fluorescent dyes, probes, biosensors, and labeling technologies for cell imaging.

A scientist working at a bench, using tweezers to manipulate a blotting membrane
Western Blotting Tools

Reagents, consumables, and equipment for electrophoresis and detection.

MILLIPEX® Multiplexing Immunoassay reagents next to a Luminex® instrument
Immunoassay Platform Solutions

Biomarker data you can trust for best next-step decisions.

96-well and 384-well MultiScreen® filter plates
MultiScreen® Filter Plates

Filtration plates for cell-based assays, ELISpot, ligand binding, and more.

96-well and 384-well MultiScreen® filter plates
MULTI-seq Lipid-Modified Oligos

Multiplexed scRNA-seq for gene expression analysis.


Related Articles

  • Pooled CRISPR Screening

    CRISPR lentiviral products are powerful research tools for the discovery of novel targets essential to human health and disease. As a world leader in the production of lentiviral libraries, we design and build custom pools to any specifications.

  • MULTI-seq Sample Multiplexing for Single Cell Analysis

    scRNA-seq is a powerful tool to analyze gene expression at the single-cell level. MULTI-seq was developed to multiplex sample types, allowing for multiple samples to be pooled together in the same single-cell analysis workflow.

  • The ELISpot Assay Enables Functional Analysis of Cellular Immunology

    Recent improvements to the design of multiwell microplates, including use of membranes with reduced background fluorescence, have bolstered the widespread application of ELISpot assays.

  • Designing Peptides

    When selecting peptides for custom synthesis, several important factors should be considered during the design process. These considerations include sequence length, solubility, and sequence stability.

  • Primary Cell Culture Basics

    A comprehensive overview of animal and human primary cell lines and media and how they are used in cell culture applications.


Related Video


Explore our Products & Services

Sign In To Continue

To continue reading please sign in or create an account.

Don't Have An Account?