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Coronavirus COVID-19 (SARS-CoV-2) Detection, Characterization, Vaccine and Therapy Production

Coronavirus COVID-19 (SARS-CoV-2) Detection, Characterization, Vaccine and Therapy Production

Expediting Your COVID-19 Response, Vaccine Research, Therapeutic Development

As a global life science supplier, we are here to help in the response to COVID-19. From supplying raw materials and research products for detection and characterization to production, we’ve consolidated relevant product and service offerings within a single page.

Current events around the spread of COVID-19 and its impact on public health continue to evolve. During this extraordinary time, we are committed to providing researchers, developers and manufacturers with the necessary products and services to aid the COVID-19 response. As such, our top priorities remain the safety and well-being of our employees, meeting the needs of our customers, providing accurate, timely, information, and ensuring business continuity.

We have mobilized a global task force to actively evaluate the overall supply chain of both our products and key raw material suppliers to mitigate any potential disruption. Leveraging business continuity plans, we remain dedicated to supplying our customers in all markets and providing support to the scientific efforts under way around the world, with products and services supporting both the detection of COVID-19 and the development of vaccines and therapies.

Questions regarding our products relevant to SARS-CoV-2 and the COVID-19 response? We have technical experts prioritized to help.

Call (800) 325-5832 or Email COVID-19@milliporesigma.com.

For support in your local language you can find the contact information here.

This page will be regularly updated with new products and information.


Virus Detection

We are committed to providing researchers with the reagents and technical expertise for timely support of the SARS-CoV-2 outbreak. Explore our offering across viral RNA purification, RT-PCR, RT-qPCR, Immunoassay, and supporting reagents that are suitable for SARS-CoV-2 diagnostics assay development.

See a comprehensive overview of our solutions for Immunoassay and Molecular Dx assay development.

SARS-CoV-2 qPCR Assay Designs, Primers, Probes, and Controls

Our scientists have created qPCR assay designs for detection of SARS-CoV-2 for open use. For the designs in the tables below, review our existing SARS-CoV-2 target detection information around assay design and reactivity; primer and probe design; and, genetic analysis.

For research use only. Not for use in diagnostic procedures.

SARS-CoV-2 qPCR Detection Assays

SARS Positive Control qPCR Assay

Predesigned Primers & Probes

Our qPCR assay designs above are available for immediate ordering from our KiCqStart® product lines.

Custom Primers & Probes

To request a quote for custom primers and probes, please email dnaoligos@milliporesigma.com.

Custom Positive Controls

The SARS-CoV-2 virus has a positive-sense ssRNA genome. We offer in vitro transcribed ssRNA against regions of this genome, which can serve as positive controls. We can synthesize custom sequences from 150 to 420 nucleotides (to ensure successful manufacturing, please avoid sequences with inverted repeats and repetitions).

To request a quote or additional help, please email sirnarequest@milliporesigma.com.

SARS-CoV-2 qPCR Assay Designs, Primers, Probes, and Controls

In support of quality assurance efforts, the SARS-CoV-2 proficiency testing kit is designed for use with assays like real-time RT-PCR which detect the viral RNA by nucleic acid amplification. Reports provide evaluation of qualitative results as well as quantitative properties such as Cq(Ct) values and efficiencies.

Molecular Analysis and Supporting Reagents

SARS-CoV-2 positive control

Single stranded RNA (ssRNA) Reference Material intended for the use as a positive quality control sample for coronavirus SARS-CoV-2 in real-time RT-PCR assays.

RT-PCR Analysis

Reagents and tools collected here for viral genetics research include nucleid acid purification (NAP) kits for viral RNA purification, high-efficiency systems for RT-PCR and quantitative RT-PCR, cDNA synthesis kits, and more. One-step kits can simplify and accelerate gene amplification across a wide dynamic range. Viral RNA extraction buffer lyses viral particles and stabilizes RNA from saliva ready for direct analysis via RT-qPCR with no additional cleanup step.

Immunoassays

Antibodies & Antigens

*New* Antibodies for Viral Antigen Test Development

*New* Mouse monoclonal anti-SARS-CoV-2 nucleocapsid antibody clones tested for use in Lateral Flow Assay and ELISA.

*New* SARS-CoV-2 Antigens

*New* 2019nCoV Nucleocapsid full-length antigens tested for use in Lateral Flow Assay.

Antibodies for Serology Assay Development

Antibody product range useful for subclassification of human immunoglobulins (IgM, IgG, IgA) in whole blood for serological assay development. Mouse monoclonal anti-Human IgG and IgM validated for use in Lateral Flow Assay and ELISA.

Microspheres & Nanoparticles

*New* Estapor® Europium Fluorescent Microspheres for enhanced quantitative Lateral Flow assay development. Significant improvements in sensitivity due to longer Stokes shift, reduced background noise, and enhanced quantum yield. Carboxylated surface (-COOH) for easy protein conjugation.

We also offer 300-500nm COOH-Fluorescent microspheres, COOH-Dyed microspheres and magnetic microspheres for automated immunoassay platforms.

Estapor® Europium and Fluorescent Microspheres

Dyed Estapor® Microspheres of 300nm

Estapor® Magnetic Microspheres

Gold Nanoparticles

Gold nanoparticles (20-50 nm) and our gold nanoparticle kits provide an easy way to customize your colorimetric lateral flow test to your antibody of choice. Gold nanoparticles are chemically inert, have a long shelf life, and exhibit exceptional optical properties, making them one of the most widely used choices for Lateral Flow Assays. Download our Bioconjugation Handbook.

Probumin

Diagnostic Grade BSA for protease sensitive immunoassays and as a stabilizing agent for protein reagents requiring low IgG levels; may be used for molecular biology applications. Purity is ≥ 98%; typical purity is 100%.

ProClin™ 300

Biocide designed specifically for use within Diagnostics manufacturing applications only. An effective, environmentally-friendly alternative to existing diagnostic reagent preservatives. At recommended usage levels, ProClin™ presents no health hazards, toxicological problems or disposal issues.

Ultrapure Water

With rapidly evolving and diverse research projects, changing priorities, multiple users and limited space, it’s critical for laboratories to select equipment that is versatile, innovative and flexible to their space requirements. Our Milli-Q® IQ 7000 ultrapure water system and its application filters tick all these boxes.

Key Components for Viral Transport Media

The CDC recently published method for labs to create their own viral transport media. Refer to SOP#: DSR-052-01: Preparation of Viral Transport Media. Specimens can be stored for up to 72 hours at 4℃.

Essential Components for Viral Transport Media


In an effort to ensure that accurate information related to MilliporeSigma products are available and conveyed, MilliporeSigma has created this website to consolidate, at a single source, all information related to our products that may be relevant to the COVID-19 pandemic. If you have questions about the virus, please visit the World Health Organization’s COVID-19 website.