All Photos(3)

117323

Sigma-Aldrich

4,4′-Methylene-bis(2-chloroaniline)

85%

Synonym(s):
4,4′-Diamino-3,3′-dichlorodiphenylmethane, 2,2′-Dichloro-4,4′-methylenedianiline
Linear Formula:
CH2[C6H3(Cl)NH2]2
CAS Number:
Molecular Weight:
267.15
Beilstein:
1882318
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.23

Quality Level

assay

85%

bp

202-214 °C/0.3 mmHg (lit.)

mp

102-107 °C (lit.)

SMILES string

Nc1ccc(Cc2ccc(N)c(Cl)c2)cc1Cl

InChI

1S/C13H12Cl2N2/c14-10-6-8(1-3-12(10)16)5-9-2-4-13(17)11(15)7-9/h1-4,6-7H,5,16-17H2

InChI key

IBOFVQJTBBUKMU-UHFFFAOYSA-N

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Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Muta. 2

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

235.4 °F - closed cup

Flash Point(C)

113 °C - closed cup

Certificate of Analysis

Certificate of Origin

R E Savage et al.
Journal of occupational and environmental medicine, 40(2), 125-135 (1998-03-21)
Many bladder cancers are indolent, and since there are no biomarkers to predict progression, the prognosis is problematic. Utilizing an in vitro/in vivo human uroepithelial cell (SV-HUC.PC) transformation system, we investigated several molecular events occurring along the continuum of exposure
Chiu-Shong Liu et al.
Environmental health perspectives, 113(6), 771-774 (2005-06-03)
A 52-year-old male chemical worker was admitted to the hospital with a history of paroxysmal microscopic hematuria for about 2 years and nocturia with gross hematuria about five times per night for 2 months. He was a nonsmoker and denied
J Cocker et al.
International journal of hygiene and environmental health, 210(3-4), 383-386 (2007-02-27)
The UK Health and Safety Laboratory (HSL) provides research and analytical support to the Health and Safety Executive, other Government Departments and employers. In the area of biomonitoring HSL conducts research studies and provides an analytical service for regular surveillance
4,4'-Methylenebis(2-chloroaniline).
Report on carcinogens : carcinogen profiles, 12, 262-264 (2011-08-24)
Abid Dost et al.
Occupational medicine (Oxford, England), 59(6), 402-405 (2009-07-01)
To monitor the occurrence of cancer in a recently defined cohort of UK workers engaged in the manufacture of polyurethane elastomers using 4,4'-methylene-bis-ortho-chloroaniline. A cohort of 308 male production workers from seven factories have been enumerated. All employees had a

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