ultrapure grade, ≥99.9%

Tris base, Trometamol, 2-Amino-2-(hydroxymethyl)-1,3-propanediol, THAM
Linear Formula:
CAS Number:
Molecular Weight:
Beilstein/REAXYS Number:
EC Number:
MDL number:
PubChem Substance ID:


ultrapure grade



useful pH range

7 - 9

pKa (25 °C)



219-220 °C/10 mmHg (lit.)


167-172 °C (lit.)


water: 0.66 g/mL, clear, colorless

SMILES string




InChI key


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Buffer and primary pH standard. pKa=8.3 at 20°C. Auxiliary material in pharmaceutical science.

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Certificate of Analysis

Certificate of Origin

  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. What does the "ultrapure grade" in the description of Product 154563, Tris(hydroxymethyl)aminomethane, indicate?

    This material has been specifically purified to have the lowest heavy metals and iron content.

  4. What solvents can be used to dissolve Product T54563, Trometamol?

    According to the chemicals encyclopedia published by the Royal Society of Chemistry (which we also offer as Product No. Z705322), this material is expected to be soluble in water (550 mg/mL), ethylene glycol (79.1 mg/mL), methanol (26 mg/mL), anhydrous ethanol (14.6 mg/mL), 95% ethanol (22 mg/mL), dimethylformamide (14mg/mL) and acetone (2mg/mL) at room temperature.

  5. Where can I find more technical information on Product T54563, Trometamol, and other buffers?

    Please visit the Learning Center in our Buffer Explorer section of the website. There you will find helpful formulas, buffer calculator tools and other property information on our buffer products.

  6. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  7. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

  9. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

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Corey A Baron et al.
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An acquisition method that does not increase scan time or specific absorption rate is investigated for reducing the deleterious effects of cerebrospinal fluid (CSF) partial volume effects on diffusion tensor imaging (DTI) tractography. It is based on using a shorter...
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A rhenium tris-carbonyl derivative has been designed to couple infrared and luminescent detection in cells. Both spectroscopies are consistent with one another; they point out the reliability of the present SCoMPI (for Single Core Multimodal Probe for Imaging) for bimodal...

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