Discovery of 1-[2-(2, 4-dimethylphenylsulfanyl) phenyl] piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder.
Bang-Andersen B, et al.
Journal of Medicinal Chemistry, 54(9), 3206-3221 (2011)
Synthesis and dual D2 and 5-HT1A receptor binding affinities of 5-piperidinyl and 5-piperazinyl-1 H-benzo [d] imidazol-2 (3 H)-ones.
Journal of Enzyme Inhibition and Medicinal Chemistry, 29(2), 281-291 (2014)
Conformationally rigid derivatives of WAY-267,464: Synthesis and pharmacology at the human oxytocin and vasopressin-1a receptors.
Jorgensen WT, et al.
European Journal of Medicinal Chemistry, 143, 1644-1656 (2018)
Synthesis and biological evaluation of new 2-(6-alkyl-pyrazin-2-yl)-1H-benz [d] imidazoles as potent anti-inflammatory and antioxidant agents.
Shankar B, et al.
Medicinal Chemistry Research, 26(9), 1835-1846 (2017)
Journal of enzyme inhibition and medicinal chemistry, 29(2), 281-291 (2013-03-16)
A series of new 5-piperidinyl and 5-piperazinyl-1H-benzo[d]imidazol-2(3H)-ones have been synthesized and evaluated for dual D2 and 5-HT1A receptor binding affinities. The synthesized ligands are structurally related to bifeprunox, a potential atypical antipsychotic, having potent D2 receptor antagonist and 5-HT1A receptor...