All Photos(1)

176923

Sigma-Aldrich

1,3-Difluoro-2-propanol

99%

Linear Formula:
FCH2CH(OH)CH2F
CAS Number:
Molecular Weight:
96.08
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22

Quality Level

assay

99%

contains

sodium fluoride as stabilizer

refractive index

n20/D 1.373 (lit.)

bp

54-55 °C/34 mmHg (lit.)

density

1.24 g/mL at 25 °C (lit.)

SMILES string

OC(CF)CF

InChI

1S/C3H6F2O/c4-1-3(6)2-5/h3,6H,1-2H2

InChI key

PVDLUGWWIOGCNH-UHFFFAOYSA-N

Application

1,3-Difluoro-2-propanol was used in the synthesis of 1,3-difluoroacetone.

Packaging

1 g in glass bottle

Pictograms

FlameExclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

107.6 °F - closed cup

Flash Point(C)

42 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

M G Feldwick et al.
Journal of biochemical and molecular toxicology, 12(1), 41-52 (1998-01-01)
Administration to rats of 1,3-difluoro-2-propanol (100 mg kg-1 body weight), the major ingredient of the pesticide gliftor, resulted in accumulation of citrate in the kidney after a 3 hour lag phase. 1,3-Difluoro-2-propanol was found to be metabolized to 1,3-difluoroacetone and...
K I Menon et al.
Journal of biochemical and molecular toxicology, 15(1), 47-54 (2001-02-15)
The biochemical toxicology of 1,3-difluoroacetone, a known metabolite of the major ingredient of the pesticide Gliftor (1,3-difluoro-2-propanol), was investigated in vivo and in vitro. Rat kidney homogenates supplemented with coenzyme A, ATP, oxaloacetate, and Mg2+ converted 1,3-difluoroacetone to (-)-erythro-fluorocitrate in...
M J Garle et al.
Xenobiotica; the fate of foreign compounds in biological systems, 29(5), 533-545 (1999-06-24)
1. This study has examined the ability of dichloropropanols, haloalcohols and their putative metabolites to deplete glutathione when incubated with liver fractions obtained from untreated and differentially induced rats. 2. 1,3-Dichloropropan-2-ol and 2,3-dichloropropan-1-ol (0-1000 microM) both depleted glutathione in a...

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