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184314

Sigma-Aldrich

Tetrahydrofuran-d8

≥99.5 atom % D

Synonym(s):
Deuterated tetrahydrofuran, Octadeuterotetrahydrofuran, THF-d8
Empirical Formula (Hill Notation):
C4D8O
CAS Number:
Molecular Weight:
80.16
Beilstein:
111854
MDL number:
PubChem Substance ID:
NACRES:
NA.21

Quality Level

isotopic purity

≥99.5 atom % D

assay

≥99% (CP)

form

liquid

application(s)

NMR: suitable

impurities

≤0.03% water
water

refractive index

n20/D 1.403 (lit.)

bp

65-66 °C (lit.)

mp

−106 °C (lit.)

density

0.985 g/mL at 25 °C (lit.)

mass shift

M+8

storage temp.

2-8°C

SMILES string

[2H]C1([2H])OC([2H])([2H])C([2H])([2H])C1([2H])[2H]

InChI

1S/C4H8O/c1-2-4-5-3-1/h1-4H2/i1D2,2D2,3D2,4D2

InChI key

WYURNTSHIVDZCO-SVYQBANQSA-N

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General description

Tetrahydrofuran-d8 (THF-d8), a deuterated derivative of tetrahydrofuran, is a standard purity solvent suitable for routine NMR analyses (conducted at ambient temperatures where quality is less critical). It participates as a solvent in an intermolecular proton exchange reaction between methanol and acetic acid. Kinetics of this reaction has been studied by ′H NMR line shape analysis. Infrared spectral studies of THF and THF-d8 have been investigated in the range of 10 and 300cm-1.
Tetrahydrofuran-d8 may be used as a solvent in the synthesis of deuteriotris[bis(trimethylsilyl)amido]thorium and deuteriotris[bis(trimethylsiiyl)amido]uranium.

Packaging

1, 5, 10 g in ampule

Signal Word

Danger

Hazard Statements

Hazard Classifications

Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

Target Organs

Respiratory system

Supplementary Hazards

Storage Class Code

3 - Flammable liquids

WGK Germany

WGK 1

Flash Point(F)

0.5 °F

Flash Point(C)

-17.5 °C

Certificate of Analysis

Certificate of Origin

Far-Infrared Spectrum of Tetrahydrofuran: Spectroscopic Evidence for Pseudorotation.
Lafferty WJ, et al.
J. Chem. Phys. , 42(8), 2915-2919 (1965)
Dynamic NMR study of the interference between cyclic proton exchange, selfassociation and hindered rotation of diphenylformamidine in tetrahydrofuran.
Meschede L, et al.
Berichte der Bunsengesellschaft fur physikalische Chemie, 92(4), 469-485 (1988)
NMR lineshape theory of superimposed intermolecular spin exchange reactions and its action to the system acetic acid/methanol/tetrahydrofuran-d8.
Limbach HH.
Journal of Magnetic Resonance, 36(3), 287-300 (1979)
Alejandro G Lichtscheidl et al.
Dalton transactions (Cambridge, England : 2003), 44(36), 16156-16163 (2015-08-22)
The synthesis and full characterization, including Nuclear Magnetic Resonance (NMR) data ((1)H, (13)C{(1)H} and (119)Sn{(1)H}), for a series of Me3SnX (X = O-2,6-(t)Bu2C6H3 (), (Me3Sn)N(2,6-(i)Pr2C6H3) (), NH-2,4,6-(t)Bu3C6H2 (), N(SiMe3)2 (), NEt2, C5Me5 (), Cl, Br, I, and SnMe3) compounds in...

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