3,3,5,5-Tetramethyl-1-pyrroline N-oxide


Empirical Formula (Hill Notation):
CAS Number:
Molecular Weight:
MDL number:
PubChem Substance ID:
Pricing and availability is not currently available.




73 °C/1 mmHg (lit.)


58-61 °C (lit.)

storage temp.


SMILES string




InChI key


General description

The ESR spectrum of 3,3,5,5-tetramethyl-1-pyrroline N-oxide was studied.


3,3,5,5-Tetramethyl-1-pyrroline N-oxide was used as a spin traping reagent.


250 mg in amber glass bottle

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves


NONH for all modes of transport

WGK Germany


Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Shing-Jong Huang et al.
Solid state nuclear magnetic resonance, 29(4), 272-277 (2005-11-09)
We show that a Gaussian-shaped pulse can be used to excite selected 1H signals in hydroxyapatite, monetite and H-Y zeolite loaded with trimethylphosphine oxide (TMPO). This selective excitation method can be incorporated into Lee-Goldburg (LG) cross-polarization to obtain useful spectral...
M J Davies et al.
The Biochemical journal, 240(3), 789-795 (1986-12-15)
Spin trapping using 5,5-dimethyl-1-pyrroline N-oxide (DMPO) has been used to detect and distinguish between the carbon-centred, alkoxyl, and peroxyl radicals produced during the photolytic decomposition of hydroperoxides. Photolysis of tert-butyl and cumene hydroperoxides, and peroxidized fatty acids, in toluene, with...
D De Bono et al.
Free radical research, 20(5), 327-332 (1994-05-01)
The hydroxyl radical adducts of 5,5 dimethyl-1-pyrolline-N-oxide (DMPO) and 3,3,5,5 tetramethyl-1-pyrolline-N-oxide (TMPO) formed in the presence of hydrogen peroxide and FeII are normally quite stable, but in the presence of 5-20 micromolar myoglobin their ESR signals decay rapidly. This decay...
J F Torres-Roca et al.
Journal of immunology (Baltimore, Md. : 1950), 165(9), 4822-4830 (2000-10-25)
The roles of oxygen and reactive oxygen intermediates in apoptosis are unclear at present. Although oxygen and reactive oxygen intermediates are not required for the execution of apoptosis, oxygen may be involved in at least some forms of apoptosis. In...
M Culcasi et al.
Biochemical and biophysical research communications, 164(3), 1274-1280 (1989-11-15)
A new approach for in vivo spin trapping and quantitation of oxygen-derived free radicals has been developed using a continuous flow high speed ESR detection system. Spin adducts of OH. were detected as 1:1:1:1:1:1 sextets (aN=15.2 G, aH=16.8 G, g=2.0055)...

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