357405

Sigma-Aldrich

Zirconium(IV) chloride

≥99.9% trace metals basis

Synonym(s):
Zirconium tetrachloride, Tetrachlorozirconium
Linear Formula:
ZrCl4
CAS Number:
Molecular Weight:
233.04
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.23
Pricing and availability is not currently available.

Quality Level

vapor pressure

1 mmHg ( 190 °C)

assay

≥99.9% trace metals basis

form

powder

reaction suitability

reagent type: catalyst
core: zirconium

transition temp

sublimation point 331 °C

density

2.8 g/mL at 25 °C (lit.)

Featured Industry

Battery Manufacturing

SMILES string

Cl[Zr](Cl)(Cl)Cl

InChI

1S/4ClH.Zr/h4*1H;/q;;;;+4/p-4

InChI key

DUNKXUFBGCUVQW-UHFFFAOYSA-J

Looking for similar products? Visit Product Comparison Guide

Application

Zirconium (IV) chloride acts as an efficient Lewis acid catalyst for various reactions; such as:
  • electrophilic addition reaction of indole with aldehydes/ketones to form bis(indolyl)methanes. electrophilic amination of activated arenes,
  • transthioacetylization of acetals,
  • deoxygenation of heterocyclic-N-oxides,
  • reduction of nitro compounds,
  • conversion of carbonyl compounds to 1,3-oxathiolanes,
  • Biginelli reaction for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones,
  • direct amide coupling of non activated carboxylic acids and amines,
  • synthesis of quinoxalines and pyrido[2,3-b]pyrazines,
  • deprotection of t-butyldimethylsilyl (TBDMS) ethers.
Activates pyrrolidines for improved conversion, via a modified Bouveault reaction, to the corresponding α,α-dimethylamines.

Packaging

10, 100 g in glass bottle

Pictograms

Corrosion

Signal Word

Danger

Hazard Statements

Precautionary Statements

Supp Hazards

EUH014 - EUH071

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

UN 2503 8 / PGIII

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Eagleson M
Concise Encyclopedia Chemistry null
Zirconium(IV) Chloride - Catalysed Reaction of Indoles: An Expeditious Synthesis of Bis(indolyl)methanes
Nagawade RR, et al.
Bull. Korean Chem. Soc., 26(12) (2005)
Zirconium(IV) chloride as versatile catalyst for the expeditious synthesis of quinoxalines and pyrido[2,3-b]pyrazines under ambient conditions
Aghapoor K, et al.
Transition Metal Chemistry, 35(1), 49-53 null
Aldrichimica Acta, 18, 31-31 (1985)
Direct Amide Coupling of Non-activated Carboxylic Acids and Amines Catalysed by Zirconium(IV) Chloride
Lundberg H, et al.
Chemistry (Weinheim An Der Bergstrasse, Germany), 18(13), 3822-3826 null
Articles
In the last two decades, a new method termed solid-state metathesis (SSM) has been developed to synthesize compounds that are often difficult to produce conventionally.
Read More

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service

Social Media

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon

MilliporeSigma

Research. Development. Production.

We are a leading supplier to the global Life Science industry with solutions and services for research, biotechnology development and production, and pharmaceutical drug therapy development and production.

© 2021 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved.

Reproduction of any materials from the site is strictly forbidden without permission.