363782

Sigma-Aldrich

3′-Fluoroacetanilide

98%

Linear Formula:
CH3CONHC6H4F
CAS Number:
Molecular Weight:
153.15
EC Number:
MDL number:
PubChem Substance ID:
Pricing and availability is not currently available.

assay

98%

mp

82-84 °C (lit.)

solubility

methanol: soluble 25 mg/mL, clear, colorless to yellow

SMILES string

CC(=O)Nc1cccc(F)c1

InChI

1S/C8H8FNO/c1-6(11)10-8-4-2-3-7(9)5-8/h2-5H,1H3,(H,10,11)

InChI key

AQLLDCFUQXGLHM-UHFFFAOYSA-N

General description

3′-Fluoroacetanilide is a substituted acetanilide. Fieldel-Crafts acylation of 3-fluoroacetanilide with chloroacetyl chloride is reported to yield 2′-fluoro-4′-acteamido-2-(1H-1,2,4-triazole-1-yl) acetophenone. Nitration of 3-fluoroacetanilide with nitronium tetrafluoroborate is reported.

Packaging

25 g in glass bottle

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

3

E Livni et al.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology, 19(2), 191-199 (1992-02-01)
[4-18F] 2-(2,4-difluorophenyl)-1,3-bis(1H-1,2,4-triazol-l-yl)-2-propanol [( 4-18F] fluconazole) was synthesized from its amino precursor. Fieldel-Crafts acylation of 3-fluoroacetanilide with chloroacetyl chloride produced 2'-fluoro-4'-acteamido-2-(1H-1,2,4-triazole-1-yl) acetophenone in 12% yield. Sequential reaction with (1) dimethylsulphoxonium methylide and (2) 1,2,4-triazole followed by in situ hydrolysis resulted in...
Nitrations of acetanilides by reagents of NO2X type.
Lynch BM, et al.
Canadian Journal of Chemistry, 46(7), 1141-1152 (1968)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service

Social Media

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon

MilliporeSigma

Research. Development. Production.

We are a leading supplier to the global Life Science industry with solutions and services for research, biotechnology development and production, and pharmaceutical drug therapy development and production.

© 2021 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved.

Reproduction of any materials from the site is strictly forbidden without permission.