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Quality Level




−26.5 °C (lit.)

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General description

1,1,1,2-Tetrafluoroethane is used as a trifluorovinylating agent in organic synthesis. It is identified as a potential refrigerant used in place of chlorofluorocarbons. 1,1,1,2-Tetrafluoroethane can also be used as a solvent and medical propellant for a wide range of applications. It is used to extract materials of natural origin like natural flavors, fragrances, and nutraceuticals.


1,1,1,2-Tetrafluoroethane can be used:
  • As a solvent in the preparation of cross-linked polymer microspheres through the dispersion polymerization method.
  • As a porogenic solvent in the preparation of porous polymethacrylate monolith via free radical polymerization.
  • In the synthesis of trifluorovinyllithium, a key intermediate for the preparation of 2-halo-2,3-dideoxy-arabinose derivatives of biological importance.


100 g in Sure-Pac™

Recommended products

Brass hose adapter Z146811 or brass body mini gas regulator Z513539 is recommended.


Gas cylinder

Signal Word


Hazard Statements

Precautionary Statements


UN 3159 2.2

WGK Germany


Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

P D Levin et al.
British journal of anaesthesia, 92(6), 865-869 (2004-05-04)
1,1,1,2 Tetrafluoroethane is a hydrofluoroalkane (HFA) that is replacing chlorofluorocarbons (CFC) as a medical aerosol propellant in an attempt to reduce damage to the ozone layer. This study compared the effects of HFA- and CFC-based inhalers on four anaesthetic gas...
Synthesis of porous cross-linked polymer monoliths using 1, 1, 1, 2-tetrafluoroethane (R134a) as the porogen
Hebb AK, et al.
Composites Science and Technology, 63(16), 2379-2387 (2003)
Yongwon Seo et al.
Environmental science & technology, 38(17), 4635-4639 (2004-10-06)
A new separation method using gas hydrate formation is proposed for separating HFC-134a from gas mixtures containing N2 and HFC-134a. The feasibility of this separation method was investigated from various points of view. First, to determine the mixed hydrate stability...
1, 1, 1, 2-Tetrafluoroethane; from refrigerant and propellant to solvent
Corr S
Journal of Fluorine Chemistry, 118(1-2), 55-67 (2002)
Yang Chen et al.
Pharmaceutical research, 32(9), 2928-2936 (2015-03-20)
This study investigated the effect of different active pharmaceutical ingredients (API) on aerosol electrostatic charges and aerosol performances for pressurized metered dose inhalers (pMDIs), using both insulating and conducting actuators. Five solution-based pMDIs containing different API ingredients including: beclomethasone dipropionate...

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