43124

1-(Diphenylmethyl)piperazine

≥98.0% (NT)

• Synonym(s): 1-Benzhydrylpiperazine
• Empirical Formula (Hill Notation): C₁₇H₂₀N₂
• CAS Number: 841-77-0
• Molecular Weight: 252.35
• Beilstein: 222773
• EC Number: 212-667-7
• MDL number: MFCD00038379
• PubChem Substance ID: 57650151

Properties

• Quality Level: 100
• assay: ≥98.0% (NT)
• impurities: ≤5.0% water
• SMILES string: C1CN(CCN1)C(c2ccccc2)c3ccccc3
• InChI: 1S/C17H20N2/c1-3-7-15(8-4-1)17(16-9-5-2-6-10-16)19-13-11-18-12-14-19/h1-10,17-18H,11-14H2
• InChI key: NWVNXDKZIQLBNM-UHFFFAOYSA-N

Description

General description

1-(Diphenylmethyl)piperazine is an intermediate during drug synthesis. It has been reported to be formed during the oxidative metabolism of cinnarizine (CZ) [1-(diphenylmethyl)-4-(3-phenyl-2-propenyl)-piperazine] in rat liver microsomes. It reacts with quinone in acetonitrile, followed by oxidation with an alkaline potassium ferricyanide, to afford 4-amino-3,6-di(tert-butyl)-o-benzoquinones.

Application

1-(Diphenylmethyl)piperazine [N-(Diphenylmethyl)piperazine] may be used for the synthesis of 2-nitro-3,4,4-trichloro-1-(propylthio)-1-[4-(diphenylmethyl)piperazin-1-yl]-1,3-butadiene and 2-nitro-3,4,4-trichloro-1-(octadecylthio)-1-[4-(diphenylmethyl)piperazin-1-yl]-1,3-butadiene.

Packaging

100 g in poly bottle

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves