468916

Sigma-Aldrich

[3S-(3α,4aβ,8aβ)]-N-(tert-Butyl)decahydro-3-isoquinolinecarboxamide

98%

Empirical Formula (Hill Notation):
C14H26N2O
CAS Number:
Molecular Weight:
238.37
MDL number:
PubChem Substance ID:
NACRES:
NA.22
Pricing and availability is not currently available.

Quality Level

assay

98%

optical activity

[α]22/D −71°, c = 1 in methanol

mp

112-115 °C (lit.)

SMILES string

CC(C)(C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2CN1

InChI

1S/C14H26N2O/c1-14(2,3)16-13(17)12-8-10-6-4-5-7-11(10)9-15-12/h10-12,15H,4-9H2,1-3H3,(H,16,17)/t10-,11+,12-/m0/s1

InChI key

UPZBXVBPICTBDP-TUAOUCFPSA-N

Related Categories

Application

Fragment present in various HIV-1 protease inhibitors currently in clinical trials for AIDS treatment.

Packaging

1 g in glass bottle

Pictograms

CorrosionExclamation mark

Signal Word

Danger

Hazard Statements

Precautionary Statements

Hazard Codes

Xn

Risk Statement

22-41-52/53

Safety Statement

22-26-39-61

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Trova, M.P. et al.
Bioorganic & Medicinal Chemistry Letters, 3, 1595-1595 (1993)
T J Tucker et al.
Journal of medicinal chemistry, 35(14), 2525-2533 (1992-07-20)
A series of HIV-1 protease inhibitors containing a novel hydroxyethyl secondary amine transition state isostere has been synthesized. The compounds exhibit a strong preference for the (R) stereochemistry at the transition state hydroxyl group. Molecular modeling studies with the prototype...

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service

Social Media

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon

MilliporeSigma

Research. Development. Production.

We are a leading supplier to the global Life Science industry with solutions and services for research, biotechnology development and production, and pharmaceutical drug therapy development and production.

© 2021 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved.

Reproduction of any materials from the site is strictly forbidden without permission.