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480894

Sigma-Aldrich

O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine

96%

Empirical Formula (Hill Notation):
C5H11NO2
CAS Number:
Molecular Weight:
117.15
MDL number:
PubChem Substance ID:
NACRES:
NA.22

assay

96%

bp

81 °C/20 mmHg (lit.)

mp

34-37 °C (lit.)

SMILES string

NOC1CCCCO1

InChI

1S/C5H11NO2/c6-8-5-3-1-2-4-7-5/h5H,1-4,6H2

InChI key

NLXXVSKHVGDQAT-UHFFFAOYSA-N

General description

O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine (OTX) is an O-substituted hydroxylamine. The coupling of OTX with alkaline gel electrophoresis has been reported to improve the process of detecting single strand breaks (SSBs) in DNA.

Application

O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine may be used in the synthesis of 2-(5-bromothiophene-2-sulfonamido)-N-(tetrahydro-2H-pyran-2-yloxy)acetamides.
It may be used in the synthesis of the following potential histone deacetylase (HDAC) inhibitors:
  • 2-[1-(naphthalene-2-sulfonyl)-heterocyclyl]-pyrimidine-5-carboxylic acid (tetrahydropyran-2-yloxy)-amides
  • (E)-3-(2-benzyl-1-oxoisoindolin-6-yl)-N-(tetrahydro-2H-pyran-2-yloxy)acrylamide
  • 3-(1-benzenesulfonyl-2,3-dihydro-1H-indol-5-yl)-N-hydroxy-acrylamide

Packaging

1 g in glass bottle

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

179.6 °F - closed cup

Flash Point(C)

82 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

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Certificate of Origin

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