All Photos(1)

482641

Sigma-Aldrich

(S)-(+)-2-Fluoro-α-methyl-4-biphenylacetic acid

98%

Synonym(s):
(S)-(+)-Flurbiprofen
Linear Formula:
C6H5C6H3(F)CH(CH3)CO2H
CAS Number:
Molecular Weight:
244.26
EC Number:
MDL number:
PubChem Substance ID:

assay

98%

optical activity

[α]24/D +43°, c = 1 in chloroform

mp

109-110 °C (lit.)

SMILES string

C[C@H](C(O)=O)c1ccc(c(F)c1)-c2ccccc2

Gene Information

human ... IL8RA(3577)

Certificate of Analysis

Certificate of Origin

Ilaria Peretto et al.
Journal of medicinal chemistry, 48(18), 5705-5720 (2005-09-02)
Flurbiprofen, a nonsteroidal antiinflammatory drug (NSAID), has been recently described to selectively inhibit beta-amyloid(1)(-)(42) (Abeta42) secretion, the most toxic component of the senile plaques present in the brain of Alzheimer patients. The use of this NSAID in Alzheimer's disease (AD)...
Marcello Allegretti et al.
Journal of medicinal chemistry, 48(13), 4312-4331 (2005-06-25)
The CXC chemokine CXCL8/IL-8 plays a major role in the activation and recruitment of polymorphonuclear (PMN) cells at inflammatory sites. CXCL8 activates PMNs by binding the seven-transmembrane (7-TM) G-protein-coupled receptors CXC chemokine receptor 1 (CXCR1) and CXC chemokine receptor 2...
Nicholas Stock et al.
Bioorganic & medicinal chemistry letters, 16(8), 2219-2223 (2006-02-04)
The subtle modification of a selection of Abeta42 inhibiting non-steroidal anti-inflammatory drugs (NSAIDs), through synthesis of the geminal dimethyl analogues, was anticipated to ablate their cyclooxygenase activity whilst maintaining Abeta42 inhibition. Methylflurbiprofen 6 exhibited similar in vitro Abeta42 inhibition to...
Tiago L Moda et al.
Bioorganic & medicinal chemistry, 15(24), 7738-7745 (2007-09-18)
A drug intended for use in humans should have an ideal balance of pharmacokinetics and safety, as well as potency and selectivity. Unfavorable pharmacokinetics can negatively affect the clinical development of many otherwise promising drug candidates. A variety of in...

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