530301

Sigma-Aldrich

2-(Chloromethyl)-3,4-dimethoxypyridine hydrochloride

97%

Synonym(s):
2-(Chloromethyl)-3,4-dimethoxypyridinium hydrochloride
Empirical Formula (Hill Notation):
C8H11Cl2NO2
CAS Number:
Molecular Weight:
224.08
Beilstein/REAXYS Number:
5360726
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22

Quality Level

assay

97%

mp

155 °C (dec.) (lit.)

SMILES string

Cl[H].COc1ccnc(CCl)c1OC

InChI

1S/C8H10ClNO2.ClH/c1-11-7-3-4-10-6(5-9)8(7)12-2;/h3-4H,5H2,1-2H3;1H

InChI key

YYRIKJFWBIEEDH-UHFFFAOYSA-N

General description

2-(Chloromethyl)-3,4-dimethoxypyridine hydrochloride (CDP) can be synthesized using maltol as a starting material. CDP and DMS (dimethyl sulfate) are used in the preparation of pantoprazole sodium (PPS), an antiulcerative drug. The quantification of CDP and DMS in PPS can be done simultaneously by gas chromatography–mass spectrometry (GC-MS) method.

Application

2-(Chloromethyl)-3,4-dimethoxypyridine hydrochloride may be used as a precursor for the preparation [(2-pyridyl)-2-ethyl]-[3,4-dimethoxy-(2-pyridylmethyl)]-N-methylamine.

Packaging

25 g in glass bottle

Signal Word

Danger

Precautionary Statements

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

UN 3077 9 / PGIII

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Validated chromatographic methods for the determination of process related toxic impurities in pantoprazole sodium.
Raman NVVSS, et al.
Chromatographia, 68(5-6), 481-484 (2008)
The Synthesis of 2-chloromethyl-3,4-dimethoxypyridine Hydrochloride.
L DL, et al.
Journal of Jiangxi Normal University (Natural Science Edition), 42-45 (2003)
fac-Cobalt (III)-azido complexes derived from substituted pyridyl-based tridentate amines.
Massoud SS, et al.
Transition Met. Chem. (London), 39(5), 585-591 (2014)

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