Diethyl azodicarboxylate solution

40 wt. % in toluene

NSC 679015, Diethoxycarbonyldiazene solution, NSC 3474, DEAD, Unifoam AZ-AE 200, Diethyl azodiformate solution, 1,2-Ethoxycarbonyl diazene solution
Linear Formula:
CAS Number:
Molecular Weight:
Beilstein/REAXYS Number:
MDL number:
PubChem Substance ID:
Pricing and availability is not currently available.

Quality Level


40 wt. % in toluene

refractive index

n20/D 1.4690


116-117 °C


0.956 g/mL at 25 °C

storage temp.


SMILES string




InChI key


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General description

DOT Special Approval Submission is Under Review. Availability is Estimated as March 2012.


Reactant for preparation of:
  • Immunostimulants α-Galactosylceramides
  • Cellotriose and cellotetraose analogues as transition state mimics for mechanistic studies of cellulases
  • Bisubstrate inhibitors with molecular recognition at the active site of catechol-O-methyltransferase
  • Derivatives of F200 and S383 with cannabinoid CB1 receptor binding activities
  • Aza-β-lactams via NHC-catalyzed 2 + 2 cycloaddition with ketenes

Reagent for:
  • Annulation of N-protected imines
  • α-thiocyanation of enolizable ketones with ammonium thiocyanate
  • Diels-Alder reactions
A commonly used activating reagent in Mitsunobo reactions.


25, 100 g in glass bottle
100g unit contains ca. 40g DEAD solute
25g unit contains ca. 10g DEAD solute


Toxic, Irritant, Flammable

Signal Word


Target Organs

Central nervous system

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Hazard Codes


Risk Statement


Safety Statement



UN3379 - DOT UN3223 class 3 - PG 1 - Desensitized explosive, liquid, n.o.s. (Diethyl Azodicarboxylate 40% solution in toluene);Hi:ALL

WGK Germany


Flash Point(F)

105.8 °F - closed cup

Flash Point(C)

41 °C - closed cup

A Fürstner et al.
The Journal of organic chemistry, 65(6), 1738-1742 (2000-04-06)
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Adrian Egli et al.
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Fany Reffuveille et al.
Antimicrobial agents and chemotherapy, 58(9), 5363-5371 (2014-07-02)
Biofilm-related infections account for at least 65% of all human infections, but there are no available antimicrobials that specifically target biofilms. Their elimination by available treatments is inefficient since biofilm cells are between 10- and 1,000-fold more resistant to conventional...
Pia Kvistborg et al.
Science translational medicine, 6(254), 254ra128-254ra128 (2014-09-19)
Anti-CTLA-4 treatment improves the survival of patients with advanced-stage melanoma. However, although the anti-CTLA-4 antibody ipilimumab is now an approved treatment for patients with metastatic disease, it remains unknown by which mechanism it boosts tumor-specific T cell activity. In particular...
Victor Y L Leung et al.
Stem cells (Dayton, Ohio), 32(8), 2164-2177 (2014-04-17)
Intervertebral disc degeneration is associated with back pain and radiculopathy which, being a leading cause of disability, seriously affects the quality of life and presents a hefty burden to society. There is no effective intervention for the disease and the...

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