661384

Sigma-Aldrich

2-Iodoxybenzoic acid

contains stabilizer, 45 wt. % (IBX)

Synonym(s):
SIBX, Stabilized IBX
Empirical Formula (Hill Notation):
C7H5IO4
CAS Number:
Molecular Weight:
280.02
MDL number:
PubChem Substance ID:
NACRES:
NA.22
Pricing and availability is not currently available.

Quality Level

contains

stabilizer

reaction suitability

reagent type: oxidant

concentration

45 wt. % (IBX)

SMILES string

OI1(=O)OC(=O)c2ccccc12

InChI

1S/C7H5IO4/c9-7-5-3-1-2-4-6(5)8(10,11)12-7/h1-4H,(H,10,11)

InChI key

CQMJEZQEVXQEJB-UHFFFAOYSA-N

Related Categories

Application

Reagent used to oxidize Fmoc-protected amino alcohols to the corresponding amino aldehydes in the presence of DMSO.
A stabilized formulation of IBX (SIBX) that displays none of the explosive properties of IBX, while maintaining excellent reactivity and selectivity.

Packaging

1, 10, 50, 250 g in glass bottle

Other Notes

The material is stabilized with benzoic acid and isophthalic acid

Signal Word

Danger

Hazard Statements

Target Organs

Lungs, Respiratory system

Supp Hazards

EUH044

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Hazard Codes

C

Risk Statement

1-35-37

Safety Statement

26-35-36/37/39-45

RIDADR

UN 1759 8 / PGII

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Aurélie Ozanne et al.
Organic letters, 5(16), 2903-2906 (2003-08-02)
[reaction: see text] SIBX is a nonexplosive formulation of IBX that can be used as a suspension in a variety of standard organic solvents such as refluxing EtOAc and THF to oxidize safely alcohols into aldehydes and ketones. The use...
Stefanie Deike et al.
Bioorganic chemistry, 101, 104012-104012 (2020-07-20)
Aggregation of amyloid peptides results in severe neurodegenerative diseases. While the fibril structures of Aβ40 and Aβ42 have been described recently, resolution of the aggregation pathway and evaluation of potent inhibitors still remains elusive, in particular in view of the...
Synthetic Communications, 37, 3493-3493 (2007)
Roberta Bernini et al.
Journal of agricultural and food chemistry, 65(31), 6506-6512 (2017-03-14)
A hydroxytyrosol (HTyr)-enriched fraction containing HTyr 6% w/w, derived from Olea europaea L. byproducts and obtained using an environmentally and economically sustainable technology, was lipophilized under green chemistry conditions. The effects of three fractions containing hydroxytyrosyl butanoate, octanoate, and oleate...
F Clemente et al.
Bioorganic chemistry, 98, 103740-103740 (2020-03-23)
The enzyme glucocerebrosidase (GCase) has become an important therapeutic target due to its involvement in pathological disorders consequent to enzyme deficiency, such as the lysosomal storage Gaucher disease (GD) and the neurological Parkinson disease (PD). Pharmacological chaperones (PCs) are small...
Articles
IBX is not often used due to the fact that it is an impact-sensitive explosive material, which prevents its shipping and transport, as well as its application in industry.
Read More

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