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Vancomycin hydrochloride hydrate

Empirical Formula (Hill Notation):
C66H75Cl2N9O24 · HCl · xH2O
CAS Number:
Molecular Weight:
1485.71 (anhydrous basis)
MDL number:
PubChem Substance ID:

optical activity

[α]21/D −28.5°, c = 1 in H2O

storage temp.


SMILES string




InChI key



Used as selective membrane mergers to study the functional determinants of synthetic vesicle fusion

Used as an antibiotic for a variety of different studies including:
  • Impact to intestinal flora with prolonged exposure to antibiotics
  • Usefulness against antibiotic resistant bacterial strains
  • Transport of nanoparticles across phospholipid membranes


1 g in glass bottle

Certificate of Analysis

Certificate of Origin

David J Tennent et al.
Journal of orthopaedic trauma, 30(10), 531-537 (2016-04-29)
To evaluate the effectiveness of locally applied vancomycin powder at different times postinfection in a contaminated traumatic animal model. This study used an established segmental defect rat femur model contaminated with Staphylococcus aureus UAMS-1 followed by treatment at 6 or...
Jan Gessmann et al.
Tissue engineering. Part A, 24(9-10), 809-818 (2017-11-04)
Platelet-free blood plasma clots were loaded either with antibiotics (vancomycin, gentamicin, or linezolid) at concentrations of 5-300 μg/mL or with silver ions (silver acetate) at concentrations of 3.3-129 μg/mL. The release of antibiotics or silver from the clot matrix was analyzed after...
Freija Van den Driessche et al.
International journal of antimicrobial agents, 49(3), 315-320 (2017-02-06)
Staphylococcus aureus biofilms are involved in a wide range of infections that are extremely difficult to treat with conventional antibiotic therapy. We aimed to identify potentiators of antibiotics against mature biofilms of S. aureus Mu50, a methicillin-resistant and vancomycin-intermediate-resistant strain....
Ling Shen et al.
Frontiers in microbiology, 11, 856-856 (2020-06-18)
Six previously undescribed ophiobolin-type sesterterpenes, namely, bipolatoxins A-F (1-6); and one previously undescribed pimarane-type diterpene, namely, 1β-hydroxy momilactone A (7); together with three known compounds, namely, 25-hydroxyophiobolin I (8), ophiobolin I (9), and ophiobolin A lactone (10); were isolated and...
Mu Cheng et al.
Antimicrobial agents and chemotherapy, 58(11), 6819-6827 (2014-09-04)
Ramoplanin is an actinomycetes-derived antibiotic with broad-spectrum activity against Gram-positive bacteria that has been evaluated in clinical trials for the treatment of gastrointestinal vancomycin-resistant enterococci (VRE) and Clostridium difficile infections. Recent studies have proposed that ramoplanin binds to bacterial membranes...

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